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Gene

DHX37

DEAH-box helicase 37

Summary

Cytogenetic location
12q24.31
Coordinates
Chromosome 12: 124,946,826–124,989,131 (GRCh38)
Exons
27 exons across 42.3 kb
Protein
1,157 amino acids
Inheritance
Autosomal dominant
Also known as
KIAA1517, MGC4322, MGC2695, Dhr1
Previous symbols
DDX37
MANE Select transcript
ENST00000308736.7NM_032656.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • 46,XY Differences of Sex Development and Gonadal Dysgenesis

    • 46,XY complete gonadal dysgenesis (Swyer syndrome)

      A condition in which people with XY chromosomes have undeveloped streak gonads and a female appearance, caused by variants in SRY, NR5A1, MAP3K1, DHH and other genes.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Streak gonads carry a high risk of gonadoblastoma, so removal is usually recommended, and hormone replacement is needed for puberty.

Broader groupings

  • Hypertrophic Cardiomyopathy

    • Autosomal dominant

      One of 62 genes linked to it

      A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Beta-blockers, non-dihydropyridine calcium channel blockers, activity restriction, genetic counseling

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How DHX37 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where DHX37 sits. DHX37 and 6 genes near it on chromosome 12, from 124,467,979 to 125,467,978.Chromosome 1212q24.31p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.33124.6 Mb124.8 Mb125 Mb125.2 Mb125.4 MbNCOR2: 124,324,407–124,567,647, reverse strandNCOR2SCARB1: 124,776,856–124,882,668, reverse strandSCARB1UBC: 124,910,297–124,939,924, reverse strandUBCDHX37: 124,946,826–124,989,131, reverse strandDHX37BRI3BP: 124,993,617–125,031,231, forward strandBRI3BPAACS: 125,065,364–125,144,564, forward strandAACSTMEM132B: 125,186,386–125,662,377, forward strandTMEM132BDiagram of DHX37: 27 exons on the reverse strand of chromosome 12Exon 18: 1 known disease-causing siteExon 15: 2 known disease-causing sitesExon 6: 1 known disease-causing siteExon 27: 124,946,826–124,947,887, 1,062 basesExon 26: 124,948,084–124,948,181, 98 basesExon 25: 124,949,986–124,950,059, 74 basesExon 24: 124,950,149–124,950,243, 95 basesExon 23: 124,950,413–124,950,550, 138 basesExon 22: 124,950,690–124,950,804, 115 basesExon 21: 124,952,398–124,952,570, 173 basesExon 20: 124,953,880–124,953,996, 117 basesExon 19: 124,954,087–124,954,211, 125 basesExon 18: 124,956,691–124,956,879, 189 basesExon 17: 124,957,029–124,957,135, 107 basesExon 16: 124,960,312–124,960,423, 112 basesExon 15: 124,964,394–124,964,626, 233 basesExon 14: 124,964,930–124,965,006, 77 basesExon 13: 124,965,668–124,965,812, 145 basesExon 12: 124,966,793–124,966,878, 86 basesExon 11: 124,967,123–124,967,218, 96 basesExon 10: 124,968,534–124,968,648, 115 basesExon 9: 124,968,867–124,968,968, 102 basesExon 8: 124,971,302–124,971,415, 114 basesExon 7: 124,972,503–124,972,599, 97 basesExon 6: 124,975,419–124,975,511, 93 basesExon 5: 124,977,342–124,977,490, 149 basesExon 4: 124,980,490–124,980,838, 349 basesExon 3: 124,982,511–124,982,623, 113 basesExon 2: 124,986,096–124,986,265, 170 basesExon 1: 124,988,917–124,989,131, 215 bases2725201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.6 kb of the gene's 42.3 kb; 3,474 of those bases code for the protein.

How a genome test reads DHX37

5

positions in DHX37 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 42.3 kb of DHX37, introns included, not only the 4.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DHX37 gene: DEAH-box helicase 37. Retrieved 17 October 2026, from https://dantelabs.com/genes/dhx37

Vancouver

Dante Labs. DHX37 gene: DEAH-box helicase 37 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dhx37

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