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Gene

ATP5PO

ATP synthase peripheral stalk subunit OSCP

Summary

Cytogenetic location
21q22.11
Coordinates
Chromosome 21: 33,903,453–33,915,804 (GRCh38)
Exons
7 exons across 12.4 kb
Protein
213 amino acids
Also known as
OSCP, ATPO
Previous symbols
ATP5O
MANE Select transcript
ENST00000290299.7NM_001697.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Primary Mitochondrial Disease

    • Combined Oxidative Phosphorylation Deficiency

      Disorders, usually caused by nuclear genes involved in mitochondrial protein production, that reduce several respiratory chain complexes at once and often cause severe multisystem disease in childhood.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing can end a diagnostic search and guide surveillance and supportive care.

How ATP5PO is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 21, with a bracket where ATP5PO sits. ATP5PO and 15 genes near it on chromosome 21, from 33,409,629 to 34,409,628.Chromosome 2121q22.11p13p12p11.2p11.1q11.1q11.2q21.1q21.2q21.3q22.11q22.12q22.13q22.2q22.333.6 Mb33.8 Mb34 Mb34.2 Mb34.4 MbIFNGR2: 33,403,205–33,479,348, forward strandIFNGR2TMEM50B: 33,432,190–33,480,004, reverse strandTMEM50BDNAJC28: 33,485,615–33,491,753, reverse strandDNAJC28GART: 33,498,517–33,543,524, reverse strandGARTSON: 33,542,214–33,577,481, forward strandSONDONSON: 33,559,542–33,589,015, reverse strandDONSON: 33,584,687–33,931,607, reverse strandCRYZL1: 33,589,341–33,643,926, reverse strandCRYZL1ITSN1: 33,642,400–33,899,861, forward strandITSN1ATP5PO: 33,903,453–33,915,804, reverse strandATP5POMRPS6: 34,072,889–34,362,252, forward strandMRPS6SLC5A3: 34,073,509–34,106,260, forward strandSLC5A3: 34,073,509–34,143,037, forward strandKCNE2: 34,180,729–34,371,390, forward strandKCNE2SMIM11: 34,375,107–34,416,961, forward strandSMIM11C21orf140: 34,400,112–34,401,072, reverse strandC21orf140Diagram of ATP5PO: 7 exons on the reverse strand of chromosome 21Exon 7: 33,903,453–33,903,639, 187 basesExon 6: 33,903,935–33,904,021, 87 basesExon 5: 33,907,341–33,907,453, 113 basesExon 4: 33,909,082–33,909,211, 130 basesExon 3: 33,912,289–33,912,399, 111 basesExon 2: 33,914,450–33,914,500, 51 basesExon 1: 33,915,728–33,915,804, 77 bases76543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.8 kb of the gene's 12.4 kb; 642 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ATP5PO gene: ATP synthase peripheral stalk subunit OSCP. Retrieved 17 October 2026, from https://dantelabs.com/genes/atp5po

Vancouver

Dante Labs. ATP5PO gene: ATP synthase peripheral stalk subunit OSCP [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/atp5po

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