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Gene

ARSL

arylsulfatase L

Summary

Cytogenetic location
Xp22.33
Coordinates
Chromosome X: 2,934,521–2,964,341 (GRCh38)
Exons
11 exons across 29.8 kb
Protein
589 amino acids
Previous symbols
CDPX, CDPX1, ARSE
MANE Select transcript
ENST00000381134.9NM_000047.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads ARSL yet. The test sequences your whole genome, so your data includes it all the same.

How ARSL is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome X, with a bracket where ARSL sits. ARSL and 9 genes near it on chromosome X, from 2,449,431 to 3,449,430.Chromosome XXp22.33p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q282.6 Mb2.8 Mb3 Mb3.2 Mb3.4 MbDHRSX: 2,217,548–2,502,805, reverse strandDHRSXZBED1: 2,486,169–2,502,862, reverse strandZBED1CD99: 2,690,988–2,741,312, forward strandCD99XG: 2,751,798–2,816,500, forward strandXGGYG2: 2,828,571–2,911,025, forward strandGYG2ARSD: 2,903,972–2,929,405, reverse strandARSDARSL: 2,934,521–2,964,341, reverse strandARSLARSH: 3,006,546–3,034,111, forward strandARSHARSF: 3,040,235–3,112,822, forward strandARSFMXRA5: 3,308,228–3,347,100, reverse strandMXRA5Diagram of ARSL: 11 exons on the reverse strand of chromosome XExon 11: 5 known disease-causing sitesExon 9: 4 known disease-causing sitesExon 7: 3 known disease-causing sitesExon 6: 2 known disease-causing sitesExon 5: 4 known disease-causing sitesExon 4: 4 known disease-causing sitesExon 3: 3 known disease-causing sitesExon 11: 2,934,521–2,935,190, 670 basesExon 10: 2,936,742–2,936,863, 122 basesExon 9: 2,938,095–2,938,257, 163 basesExon 8: 2,943,065–2,943,199, 135 basesExon 7: 2,945,998–2,946,134, 137 basesExon 6: 2,949,304–2,949,727, 424 basesExon 5: 2,953,143–2,953,265, 123 basesExon 4: 2,955,416–2,955,537, 122 basesExon 3: 2,958,274–2,958,435, 162 basesExon 2: 2,960,378–2,960,420, 43 basesExon 1: 2,964,224–2,964,341, 118 bases11109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.2 kb of the gene's 29.8 kb; 1,770 of those bases code for the protein.

How a genome test reads ARSL

31

positions in ARSL where ClinVar classes a change as pathogenic or likely pathogenic

10 of them (32%) fall in regions short reads find hard.

  • Low mappability (1 site)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (10 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 29.8 kb of ARSL, introns included, not only the 2.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ARSL gene: arylsulfatase L. Retrieved 17 October 2026, from https://dantelabs.com/genes/arsl

Vancouver

Dante Labs. ARSL gene: arylsulfatase L [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/arsl

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