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Gene

PROP1

PROP paired-like homeobox 1

Summary

Cytogenetic location
5q35.3
Coordinates
Chromosome 5: 177,992,235–177,996,242 (GRCh38)
Exons
3 exons across 4 kb
Protein
226 amino acids
MANE Select transcript
ENST00000308304.2NM_006261.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Hypogonadotropic Hypogonadism

    • Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.

      • 6 GenCC submitters rate it definitive or strong

  • Non-Acquired Combined Pituitary Hormone Deficiency

    • Combined pituitary hormone deficiency, genetic form

      Inherited deficiency of several pituitary hormones, including PROP1, POU1F1, HESX1 and related causes.

      • 6 GenCC submitters rate it definitive or strong

How PROP1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 5, with a bracket where PROP1 sits. PROP1 and 15 genes near it on chromosome 5, from 177,494,239 to 178,494,238.Chromosome 55q35.3p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.3177.6 Mb177.8 Mb178 Mb178.2 Mb178.4 MbPDLIM7: 177,482,838–177,497,664, reverse strandPDLIM7DOK3: 177,501,888–177,511,274, reverse strandDOK3DDX41: 177,511,569–177,516,979, reverse strandDDX41FAM193B: 177,519,788–177,554,601, reverse strandFAM193BTMED9: 177,592,174–177,597,242, forward strandTMED9B4GALT7: 177,600,081–177,611,056, forward strandB4GALT7FAM153A: 177,707,981–177,784,435, reverse strandFAM153APROP1: 177,992,235–177,996,242, reverse strandPROP1FAM153CP: 178,006,348–178,086,529, forward strandFAM153CPN4BP3: 178,113,167–178,127,034, forward strandN4BP3RMND5B: 178,129,068–178,152,762, forward strandRMND5BNHP2: 178,139,872–178,153,968, reverse strandNHP2GMCL2: 178,184,505–178,187,371, reverse strandGMCL2HNRNPAB: 178,204,479–178,216,389, forward strandHNRNPABPHYKPL: 178,207,127–178,233,208, reverse strandPHYKPLCOL23A1: 178,237,476–178,590,393, reverse strandCOL23A1Diagram of PROP1: 3 exons on the reverse strand of chromosome 5Exon 3: 13 known disease-causing sitesExon 2: 15 known disease-causing sitesExon 1: 7 known disease-causing sitesExon 3: 177,992,235–177,993,047, 813 basesExon 2: 177,994,106–177,994,338, 233 basesExon 1: 177,995,825–177,996,242, 418 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.5 kb of the gene's 4 kb; 681 of those bases code for the protein.

How a genome test reads PROP1

40

positions in PROP1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 4 kb of PROP1, introns included, not only the 1.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PROP1 gene: PROP paired-like homeobox 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/prop1

Vancouver

Dante Labs. PROP1 gene: PROP paired-like homeobox 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/prop1

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