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Trait
Hypergonadotropic hypogonadism
Reduced function of the gonads (testes in males or ovaries in females) associated with excess pituitary gonadotropin secretion and resulting in delayed sexual development and growth delay.
Summary
- Also called
- Hypergonadotrophic hypogonadism, Primary hypogonadism
Hypergonadotropic hypogonadismHP:0000815
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Read the genes linked to Hypergonadotropic hypogonadism, and the rest of your genome, with one test.
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Get my Genome Test64 genes linked to Hypergonadotropic hypogonadism
Changes in these genes cause rare conditions in which Hypergonadotropic hypogonadism is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| BMP15bone morphogenetic protein 15 | Always | In 1 condition |
| BMPR1Bbone morphogenetic protein receptor type 1B | Always | In 1 condition |
| DHHdesert hedgehog signaling molecule | Always | In 1 condition |
| LEPRleptin receptor | Always | In 2 conditions |
| NUP107nucleoporin 107 | Always | In 1 condition |
| SCP2sterol carrier protein 2 | Always | In 1 condition |
| SQSTM1sequestosome 1 | Always | In 1 condition |
| SRYsex determining region Y | Always | In 2 conditions |
| CYB5Acytochrome b5 type A | Very often (80–99%) | In 1 condition |
| CYP17A1cytochrome P450 family 17 subfamily A member 1 | Very often (80–99%) | In 1 condition |
| CYP19A1cytochrome P450 family 19 subfamily A member 1 | Very often (80–99%) | In 2 conditions |
| DHX37DEAH-box helicase 37 | Very often (80–99%) | In 1 condition |
| GATA4GATA binding protein 4 | Very often (80–99%) | In 1 condition |
| LEPleptin | Very often (80–99%) | In 1 condition |
| LMNAlamin A/C | Very often (80–99%) | In 2 conditions |
| MAP3K1mitogen-activated protein kinase kinase kinase 1 | Very often (80–99%) | In 1 condition |
| NR0B1nuclear receptor subfamily 0 group B member 1 | Very often (80–99%) | In 1 condition |
| NR5A1nuclear receptor subfamily 5 group A member 1 | Very often (80–99%) | In 1 condition |
| POLA1DNA polymerase alpha 1, catalytic subunit | Very often (80–99%) | In 1 condition |
| POLR1CRNA polymerase I and III subunit C | Very often (80–99%) | In 1 condition |
| POLR3ARNA polymerase III subunit A | Very often (80–99%) | In 1 condition |
| POLR3BRNA polymerase III subunit B | Very often (80–99%) | In 1 condition |
| SIL1SIL1 nucleotide exchange factor | Very often (80–99%) | In 1 condition |
| SOX9SRY-box transcription factor 9 | Very often (80–99%) | In 1 condition |
| VAMP7vesicle associated membrane protein 7 | Very often (80–99%) | In 1 condition |
| WT1WT1 transcription factor | Very often (80–99%) | In 2 conditions |
| WWOXWW domain containing oxidoreductase | Very often (80–99%) | In 1 condition |
| ZFPM2zinc finger protein, FOG family member 2 | Very often (80–99%) | In 1 condition |
| AHSGalpha 2-HS glycoprotein | Often (30–79%) | In 1 condition |
| ALMS1ALMS1 centrosome and basal body associated protein | Often (30–79%) | In 2 conditions |
| BRCC3BRCA1/BRCA2-containing complex subunit 3 | Often (30–79%) | In 1 condition |
| ITGB6integrin subunit beta 6 | Often (30–79%) | In 1 condition |
| LSSlanosterol synthase | Often (30–79%) | In 1 condition |
| MANFmesencephalic astrocyte derived neurotrophic factor | Often (30–79%) | In 1 condition |
| MRPS7mitochondrial ribosomal protein S7 | Often (30–79%) | In 1 condition |
| PRORPprotein only RNase P catalytic subunit | Often (30–79%) | In 1 condition |
| FOXL2forkhead box L2 | Sometimes (5–29%) | In 1 condition |
| GALK1galactokinase 1 | Sometimes (5–29%) | In 1 condition |
| GNASGNAS complex locus | Sometimes (5–29%) | In 2 conditions |
| LIG3DNA ligase 3 | Sometimes (5–29%) | In 1 condition |
Show 24 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| MRE11MRE11 double strand break repair nuclease | Sometimes (5–29%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Sometimes (5–29%) | In 2 conditions |
| RIN2Ras and Rab interactor 2 | Sometimes (5–29%) | In 2 conditions |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Sometimes (5–29%) | In 1 condition |
| SAMD9sterile alpha motif domain containing 9 | Sometimes (5–29%) | In 1 condition |
| TYMPthymidine phosphorylase | Sometimes (5–29%) | In 1 condition |
| ZBTB20zinc finger and BTB domain containing 20 | Sometimes (5–29%) | In 1 condition |
| FANCD2FA complementation group D2 | Rarely (1–4%) | In 1 condition |
| MGME1mitochondrial genome maintenance exonuclease 1 | Rarely (1–4%) | In 2 conditions |
| AMACRalpha-methylacyl-CoA racemase | Not recorded | In 1 condition |
| APTXaprataxin | Not recorded | In 1 condition |
| CLPPcaseinolytic mitochondrial matrix peptidase proteolytic subunit | Not recorded | In 1 condition |
| COQ2coenzyme Q2, polyprenyltransferase | Not recorded | In 1 condition |
| CTDP1CTD phosphatase 1 | Not recorded | In 1 condition |
| DCAF17DDB1 and CUL4 associated factor 17 | Not recorded | In 1 condition |
| FANCAFA complementation group A | Not recorded | In 1 condition |
| FANCBFA complementation group B | Not recorded | In 1 condition |
| FANCCFA complementation group C | Not recorded | In 1 condition |
| FANCEFA complementation group E | Not recorded | In 1 condition |
| GALTgalactose-1-phosphate uridylyltransferase | Not recorded | In 1 condition |
| LHCGRluteinizing hormone/choriogonadotropin receptor | Not recorded | In 1 condition |
| PMM2phosphomannomutase 2 | Not recorded | In 1 condition |
| SLC29A3solute carrier family 29 member 3 | Not recorded | In 1 condition |
| TWNKtwinkle mtDNA helicase | Not recorded | In 2 conditions |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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