Gene
H3-3B
H3.3 histone B
- HGNC 4765(opens in a new tab)
- Ensembl gene ENSG00000132475(opens in a new tab)
- NCBI Gene 3021(opens in a new tab)
Summary
- Cytogenetic location
- 17q25.1
- Coordinates
- Chromosome 17: 75,776,434–75,779,779 (GRCh38)
- Exons
- 4 exons across 3.3 kb
- Protein
- 136 amino acids
- Also known as
- H3.3B
- Previous symbols
- H3F3B
- MANE Select transcript
- ENST00000254810.8NM_005324.5
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads H3-3B yet. The test sequences your whole genome, so your data includes it all the same.
How H3-3B is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 2.7 kb of the gene's 3.3 kb; 411 of those bases code for the protein.
How a genome test reads H3-3B
13
positions in H3-3B where ClinVar classes a change as pathogenic or likely pathogenic
13 of them (100%) fall in regions short reads find hard.
- Segmental duplications (13 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.
A whole genome covers all 3.3 kb of H3-3B, introns included, not only the 2.7 kb of exons.
Traits linked to H3-3B
The Human Phenotype Ontology lists these as features of the rare conditions H3-3B can cause. Each trait's page lists the other genes linked to it.
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). H3-3B gene: H3.3 histone B. Retrieved 17 October 2026, from https://dantelabs.com/genes/h3-3b
Dante Labs. H3-3B gene: H3.3 histone B [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/h3-3b
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