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Gene

KL

klotho

Summary

Cytogenetic location
13q13.1
Coordinates
Chromosome 13: 33,016,423–33,066,143 (GRCh38)
Exons
5 exons across 49.7 kb
Protein
1,012 amino acids
Also known as
KLA
MANE Select transcript
ENST00000380099.4NM_004795.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads KL yet. The test sequences your whole genome, so your data includes it all the same.

How KL is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 13, with a bracket where KL sits. KL and 2 genes near it on chromosome 13, from 32,541,283 to 33,541,282.Chromosome 1313q13.1p13p12p11.2p11.1q11q12.11q12.12q12.13q12.2q12.3q13.1q13.2q13.3q14.11q14.12q14.13q14.2q14.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q3432.6 Mb32.8 Mb33 Mb33.2 Mb33.4 MbPDS5B: 32,586,315–32,778,320, forward strandPDS5BKL: 33,016,423–33,066,143, forward strandKLSTARD13: 33,103,137–33,350,685, reverse strandSTARD13Diagram of KL: 5 exons on the forward strand of chromosome 13Exon 1: 2 known disease-causing sitesExon 1: 33,016,423–33,017,259, 837 basesExon 2: 33,053,767–33,054,277, 511 basesExon 3: 33,055,047–33,055,315, 269 basesExon 4: 33,060,679–33,061,780, 1,102 basesExon 5: 33,063,849–33,066,143, 2,295 bases123455′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5 kb of the gene's 49.7 kb; 3,039 of those bases code for the protein.

How a genome test reads KL

2

positions in KL where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 49.7 kb of KL, introns included, not only the 5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KL gene: klotho. Retrieved 17 October 2026, from https://dantelabs.com/genes/kl

Vancouver

Dante Labs. KL gene: klotho [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/kl

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