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Gene

PDCD10

programmed cell death 10

Summary

Cytogenetic location
3q26.1
Coordinates
Chromosome 3: 167,683,298–167,734,892 (GRCh38)
Exons
9 exons across 51.6 kb
Protein
212 amino acids
Inheritance
Autosomal dominant
Also known as
TFAR15
Previous symbols
CCM3
MANE Select transcript
ENST00000392750.7NM_007217.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Cerebral Cavernous Malformation

    • Cerebral Cavernous Malformation 3Autosomal dominant

      Any familial cerebral cavernous malformation in which the cause of the disease is a mutation in the PDCD10 gene.

      • 4 GenCC submitters rate it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How PDCD10 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where PDCD10 sits. PDCD10 and 5 genes near it on chromosome 3, from 167,209,095 to 168,209,094.Chromosome 33q26.1p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q29167.4 Mb167.6 Mb167.8 Mb168 Mb168.2 MbZBBX: 167,239,843–167,407,874, reverse strandZBBXSERPINI2: 167,438,967–167,478,972, reverse strandSERPINI2WDR49: 167,477,789–167,653,983, reverse strandWDR49PDCD10: 167,683,298–167,734,892, reverse strandPDCD10SERPINI1: 167,735,065–167,828,461, forward strandSERPINI1GOLIM4: 168,008,552–168,096,536, reverse strandGOLIM4Diagram of PDCD10: 9 exons on the reverse strand of chromosome 3Exon 9: 5 known disease-causing sitesExon 8: 5 known disease-causing sitesExon 7: 5 known disease-causing sitesExon 6: 9 known disease-causing sitesExon 5: 10 known disease-causing sitesExon 4: 2 known disease-causing sitesExon 3: 6 known disease-causing sitesExon 9: 167,683,298–167,684,389, 1,092 basesExon 8: 167,687,234–167,687,316, 83 basesExon 7: 167,687,615–167,687,693, 79 basesExon 6: 167,695,596–167,695,722, 127 basesExon 5: 167,697,009–167,697,126, 118 basesExon 4: 167,704,842–167,704,895, 54 basesExon 3: 167,720,062–167,720,273, 212 basesExon 2: 167,734,214–167,734,350, 137 basesExon 1: 167,734,662–167,734,892, 231 bases9515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.1 kb of the gene's 51.6 kb; 639 of those bases code for the protein.

How a genome test reads PDCD10

51

positions in PDCD10 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 51.6 kb of PDCD10, introns included, not only the 2.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PDCD10 gene: programmed cell death 10. Retrieved 16 October 2026, from https://dantelabs.com/genes/pdcd10

Vancouver

Dante Labs. PDCD10 gene: programmed cell death 10 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/pdcd10

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