Trait
More than five fingers or toes on hands or feet
Clinical name: Polydactyly
A congenital anomaly characterized by the presence of supernumerary fingers or toes.
Summary
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to More than five fingers or toes on hands or feet, and the rest of your genome, with one test.
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Get my Genome Test69 genes linked to More than five fingers or toes on hands or feet
Changes in these genes cause rare conditions in which More than five fingers or toes on hands or feet is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| BBS12Bardet-Biedl syndrome 12 | Always | In 1 condition |
| BBS7Bardet-Biedl syndrome 7 | Always | In 1 condition |
| BHLHA9basic helix-loop-helix family member a9 | Always | In 1 condition |
| FLVCR1FLVCR choline and heme transporter 1 | Always | In 1 condition |
| IFT74intraflagellar transport 74 | Always | In 1 condition |
| INTUinturned planar cell polarity protein | Always | In 1 condition |
| KDM2Blysine demethylase 2B | Always | In 1 condition |
| LZTFL1leucine zipper transcription factor like 1 | Always | In 1 condition |
| MKS1MKS transition zone complex subunit 1 | Always | In 1 condition |
| TCTN2tectonic family member 2 | Always | In 1 condition |
| TMEM231transmembrane protein 231 | Always | In 1 condition |
| MEGF8multiple EGF like domains 8 | Very often (80–99%) | In 1 condition |
| RAB23RAB23, member RAS oncogene family | Very often (80–99%) | In 1 condition |
| BBS9Bardet-Biedl syndrome 9 | Often (30–79%) | In 1 condition |
| IFT56intraflagellar transport 56 | Often (30–79%) | In 1 condition |
| MAPKAPK5MAPK activated protein kinase 5 | Often (30–79%) | In 1 condition |
| PTCH1patched 1 | Often (30–79%) | In 2 conditions |
| TMEM216transmembrane protein 216 | Often (30–79%) | In 1 condition |
| TTC21Btetratricopeptide repeat domain 21B | Often (30–79%) | In 1 condition |
| ADNPactivity dependent neuroprotector homeobox | Sometimes (5–29%) | In 2 conditions |
| AFF3ALF transcription elongation factor 3 | Sometimes (5–29%) | In 1 condition |
| ARMC9armadillo repeat containing 9 | Sometimes (5–29%) | In 1 condition |
| BBS2Bardet-Biedl syndrome 2 | Sometimes (5–29%) | In 1 condition |
| CDKN1Ccyclin dependent kinase inhibitor 1C | Sometimes (5–29%) | In 1 condition |
| CEP164centrosomal protein 164 | Sometimes (5–29%) | In 1 condition |
| CREBBPCREB binding lysine acetyltransferase | Sometimes (5–29%) | In 2 conditions |
| EP300EP300 lysine acetyltransferase | Sometimes (5–29%) | In 2 conditions |
| GLI3GLI family zinc finger 3 | Sometimes (5–29%) | In 1 condition |
| H19H19 imprinted maternally expressed transcript | Sometimes (5–29%) | In 1 condition |
| HMGA2high mobility group AT-hook 2 | Sometimes (5–29%) | In 1 condition |
| IFT54intraflagellar transport 54 | Sometimes (5–29%) | In 1 condition |
| IGF2insulin like growth factor 2 | Sometimes (5–29%) | In 2 conditions |
| INSRinsulin receptor | Sometimes (5–29%) | In 1 condition |
| KIAA0586KIAA0586 | Sometimes (5–29%) | In 1 condition |
| OFD1OFD1 centriole and centriolar satellite protein | Sometimes (5–29%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Sometimes (5–29%) | In 3 conditions |
| PLAG1PLAG1 zinc finger | Sometimes (5–29%) | In 1 condition |
| PORCNporcupine O-acyltransferase | Sometimes (5–29%) | In 1 condition |
| PURApurine rich element binding protein A | Sometimes (5–29%) | In 1 condition |
| TASP1taspase 1 | Sometimes (5–29%) | In 1 condition |
Show 29 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| TMEM138transmembrane protein 138 | Sometimes (5–29%) | In 1 condition |
| WDR19WD repeat domain 19 | Sometimes (5–29%) | In 1 condition |
| WDR83OSWD repeat domain 83 opposite strand | Sometimes (5–29%) | In 1 condition |
| ZNF699zinc finger protein 699 | Sometimes (5–29%) | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Rarely (1–4%) | In 1 condition |
| DYRK1Adual specificity tyrosine phosphorylation regulated kinase 1A | Rarely (1–4%) | In 1 condition |
| FOXA2forkhead box A2 | Rarely (1–4%) | In 1 condition |
| GLI2GLI family zinc finger 2 | Rarely (1–4%) | In 1 condition |
| HESX1HESX homeobox 1 | Rarely (1–4%) | In 2 conditions |
| LHX4LIM homeobox 4 | Rarely (1–4%) | In 1 condition |
| NEU1neuraminidase 1 | Rarely (1–4%) | In 1 condition |
| NSDHLNAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL | Rarely (1–4%) | In 1 condition |
| OTX2orthodenticle homeobox 2 | Rarely (1–4%) | In 1 condition |
| POU1F1POU class 1 homeobox 1 | Rarely (1–4%) | In 1 condition |
| PROP1PROP paired-like homeobox 1 | Rarely (1–4%) | In 1 condition |
| SEMA3Esemaphorin 3E | Rarely (1–4%) | In 1 condition |
| SPRED1sprouty related EVH1 domain containing 1 | Rarely (1–4%) | In 1 condition |
| SUCLG1succinate-CoA ligase GDP/ADP-forming subunit alpha | Rarely (1–4%) | In 1 condition |
| BBS4Bardet-Biedl syndrome 4 | Not recorded | In 1 condition |
| BMP4bone morphogenetic protein 4 | Not recorded | In 1 condition |
| CDCA7cell division cycle associated 7 | Not recorded | In 1 condition |
| EBPEBP cholestenol delta-isomerase | Not recorded | In 1 condition |
| LBRlamin B receptor | Not recorded | In 1 condition |
| LMBR1limb development membrane protein 1 | Not recorded | In 1 condition |
| STAG2STAG2 cohesin complex component | Not recorded | In 1 condition |
| TMEM67transmembrane protein 67 | Not recorded | In 1 condition |
| TRIM32tripartite motif containing 32 | Not recorded | In 1 condition |
| WDR35WD repeat domain 35 | Not recorded | In 2 conditions |
| WNT7AWnt family member 7A | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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