Trait
Happy demeanor
A conspicuously happy disposition, characterized by frequent smiling and laughing, which may be contextually inappropriate or unrelated to the situation.
Summary
- Also called
- Happy demeanour
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test24 genes linked to Happy demeanor
Changes in these genes cause rare conditions in which Happy demeanor is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| JKAMPJNK1/MAPK8 associated membrane protein | Always | In 1 condition |
| RNU2-2RNA, U2 small nuclear 2 | Always | In 1 condition |
| SATB2SATB homeobox 2 | Always | In 2 conditions |
| TBC1D23TBC1 domain family member 23 | Always | In 1 condition |
| UBE3Aubiquitin protein ligase E3A | Always | In 4 conditions |
| WSB2WD repeat and SOCS box containing 2 | Always | In 1 condition |
| ZSWIM6zinc finger SWIM-type containing 6 | Always | In 1 condition |
| WDR26WD repeat domain 26 | Very often (80–99%) | In 1 condition |
| ZEB2zinc finger E-box binding homeobox 2 | Very often (80–99%) | In 3 conditions |
| ASXL1ASXL transcriptional regulator 1 | Often (30–79%) | In 1 condition |
| ATP10AATPase phospholipid transporting 10A (putative) | Often (30–79%) | In 1 condition |
| HNRNPCheterogeneous nuclear ribonucleoprotein C | Often (30–79%) | In 1 condition |
| OCA2OCA2 melanosomal transmembrane protein | Often (30–79%) | In 1 condition |
| SNRPNsmall nuclear ribonucleoprotein polypeptide N | Often (30–79%) | In 2 conditions |
| TASP1taspase 1 | Often (30–79%) | In 1 condition |
| ADNPactivity dependent neuroprotector homeobox | Sometimes (5–29%) | In 1 condition |
| ADSLadenylosuccinate lyase | Sometimes (5–29%) | In 1 condition |
| DYRK1Adual specificity tyrosine phosphorylation regulated kinase 1A | Sometimes (5–29%) | In 1 condition |
| GRIK2glutamate ionotropic receptor kainate type subunit 2 | Sometimes (5–29%) | In 1 condition |
| PRKAR1Bprotein kinase cAMP-dependent type I regulatory subunit beta | Sometimes (5–29%) | In 1 condition |
| RAB11BRAB11B, member RAS oncogene family | Sometimes (5–29%) | In 1 condition |
| TCF4transcription factor 4 | Sometimes (5–29%) | In 1 condition |
| HDAC8histone deacetylase 8 | Not recorded | In 1 condition |
| SLC9A6solute carrier family 9 member A6 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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