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Trait
Chronic diarrhea
The presence of chronic diarrhea, which is usually taken to mean diarrhea that has persisted for over 4 weeks.
Summary
- Also called
- Diarrhea, recurrent, Recurrent diarrhea, Chronic diarrhoea
- Body system
- Abnormality of the digestive system
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This page as data
Add .json to the page's address, or ask for application/json, to read it as JSON.
library(jsonlite)
url <- "https://dantelabs.com/traits/chronic-diarrhea.json"
page <- fromJSON(url)
page$trait$nameChronic diarrheaHP:0002028
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Get my Genome Test124 genes linked to Chronic diarrhea
Changes in these genes cause rare conditions in which Chronic diarrhea is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ADAadenosine deaminase | Always | In 2 conditions |
| ATP6AP1ATPase H+ transporting accessory protein 1 | Always | In 1 condition |
| B2Mbeta-2-microglobulin | Always | In 1 condition |
| BACH2BACH transcriptional regulator 2 | Always | In 1 condition |
| CARD8caspase recruitment domain family member 8 | Always | In 1 condition |
| CD3GCD3 gamma subunit of T-cell receptor complex | Always | In 1 condition |
| CHASERRCHD2 adjacent suppressive regulatory RNA | Always | In 1 condition |
| CLMPCXADR like cell adhesion molecule | Always | In 1 condition |
| CR2complement C3d receptor 2 | Always | In 1 condition |
| DCLRE1CDNA cross-link repair 1C | Always | In 2 conditions |
| DNASE2deoxyribonuclease 2, lysosomal | Always | In 1 condition |
| FLT3LGfms related receptor tyrosine kinase 3 ligand | Always | In 1 condition |
| FOXP3forkhead box P3 | Always | In 1 condition |
| GUCY2Cguanylate cyclase 2C | Always | In 2 conditions |
| HYOU1hypoxia up-regulated 1 | Always | In 1 condition |
| IGKCimmunoglobulin kappa constant | Always | In 1 condition |
| IKZF2IKAROS family zinc finger 2 | Always | In 1 condition |
| IL2RAinterleukin 2 receptor subunit alpha | Always | In 1 condition |
| IL6STinterleukin 6 cytokine family signal transducer | Always | In 1 condition |
| ITGB2integrin subunit beta 2 | Always | In 1 condition |
| JAK3Janus kinase 3 | Always | In 2 conditions |
| MAN2B2mannosidase alpha class 2B member 2 | Always | In 1 condition |
| NDC1NDC1 transmembrane nucleoporin | Always | In 1 condition |
| NFKBIANFKB inhibitor alpha | Always | In 2 conditions |
| PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | Always | In 1 condition |
| PTCRApre T cell antigen receptor alpha | Always | In 1 condition |
| RELREL proto-oncogene, NF-kB subunit | Always | In 1 condition |
| SAMD9sterile alpha motif domain containing 9 | Always | In 1 condition |
| SKIC2SKI2 subunit of superkiller complex | Always | In 1 condition |
| SLC10A2solute carrier family 10 member 2 | Always | In 1 condition |
| SLC19A1solute carrier family 19 member 1 | Always | In 1 condition |
| SLC51Asolute carrier family 51 member A | Always | In 1 condition |
| SLC51BSLC51 subunit beta | Always | In 1 condition |
| SLC5A1solute carrier family 5 member 1 | Always | In 1 condition |
| STX3syntaxin 3 | Always | In 1 condition |
| TCF3transcription factor 3 | Always | In 1 condition |
| TOM1target of myb1 membrane trafficking protein | Always | In 1 condition |
| TRAF3TNF receptor associated factor 3 | Always | In 1 condition |
| VPS45vacuolar protein sorting 45 homolog | Always | In 1 condition |
| ZAP70zeta chain of T cell receptor associated protein kinase 70 | Always | In 2 conditions |
Show 84 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| ANTXR2ANTXR cell adhesion molecule 2 | Very often (80–99%) | In 1 condition |
| BTKBruton tyrosine kinase | Very often (80–99%) | In 2 conditions |
| CHD7chromodomain helicase DNA binding protein 7 | Very often (80–99%) | In 1 condition |
| EPCAMepithelial cell adhesion molecule | Very often (80–99%) | In 1 condition |
| IL2RGinterleukin 2 receptor subunit gamma | Very often (80–99%) | In 2 conditions |
| IL7Rinterleukin 7 receptor | Very often (80–99%) | In 2 conditions |
| NBNnibrin | Very often (80–99%) | In 1 condition |
| NUDCD3NudC domain containing 3 | Very often (80–99%) | In 1 condition |
| PSMB10proteasome 20S subunit beta 10 | Very often (80–99%) | In 1 condition |
| RAG1recombination activating 1 | Very often (80–99%) | In 1 condition |
| RAG2recombination activating 2 | Very often (80–99%) | In 1 condition |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Very often (80–99%) | In 1 condition |
| SLC39A4solute carrier family 39 member 4 | Very often (80–99%) | In 1 condition |
| WASWASP actin nucleation promoting factor | Very often (80–99%) | In 2 conditions |
| AGR2anterior gradient 2, protein disulphide isomerase family member | Often (30–79%) | In 1 condition |
| ALG1ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase | Often (30–79%) | In 1 condition |
| ALKALK receptor tyrosine kinase | Often (30–79%) | In 1 condition |
| ATMATM serine/threonine kinase | Often (30–79%) | In 1 condition |
| ATP5F1AATP synthase F1 subunit alpha | Often (30–79%) | In 1 condition |
| ATP7AATPase copper transporting alpha | Often (30–79%) | In 1 condition |
| CASP8caspase 8 | Often (30–79%) | In 1 condition |
| CD3DCD3 delta subunit of T-cell receptor complex | Often (30–79%) | In 1 condition |
| COG6component of oligomeric golgi complex 6 | Often (30–79%) | In 1 condition |
| CYP27A1cytochrome P450 family 27 subfamily A member 1 | Often (30–79%) | In 1 condition |
| ETHE1ETHE1 persulfide dioxygenase | Often (30–79%) | In 1 condition |
| FCHO1FCH and mu domain containing endocytic adaptor 1 | Often (30–79%) | In 1 condition |
| HACE1HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | Often (30–79%) | In 1 condition |
| IDUAalpha-L-iduronidase | Often (30–79%) | In 1 condition |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Often (30–79%) | In 1 condition |
| IL21Rinterleukin 21 receptor | Often (30–79%) | In 1 condition |
| IRF2BP2interferon regulatory factor 2 binding protein 2 | Often (30–79%) | In 1 condition |
| IRF4interferon regulatory factor 4 | Often (30–79%) | In 1 condition |
| LIN28Blin-28 RNA binding posttranscriptional regulator B | Often (30–79%) | In 1 condition |
| LMO1LIM domain only 1 | Often (30–79%) | In 1 condition |
| LRBALPS responsive beige-like anchor protein | Often (30–79%) | In 1 condition |
| MADDMAP kinase activating death domain | Often (30–79%) | In 2 conditions |
| MAP3K14mitogen-activated protein kinase kinase kinase 14 | Often (30–79%) | In 1 condition |
| MGME1mitochondrial genome maintenance exonuclease 1 | Often (30–79%) | In 1 condition |
| MTTPmicrosomal triglyceride transfer protein | Often (30–79%) | In 1 condition |
| MVKmevalonate kinase | Often (30–79%) | In 1 condition |
| MYCNMYCN proto-oncogene, bHLH transcription factor | Often (30–79%) | In 1 condition |
| ORAI1ORAI calcium release-activated calcium modulator 1 | Often (30–79%) | In 1 condition |
| OTULINOTU deubiquitinase with linear linkage specificity | Often (30–79%) | In 1 condition |
| PHOX2Bpaired like homeobox 2B | Often (30–79%) | In 1 condition |
| POLA1DNA polymerase alpha 1, catalytic subunit | Often (30–79%) | In 1 condition |
| RBCK1RANBP2-type and C3HC4-type zinc finger containing 1 | Often (30–79%) | In 1 condition |
| RFXANKregulatory factor X associated ankyrin containing protein | Often (30–79%) | In 1 condition |
| RYR3ryanodine receptor 3 | Often (30–79%) | In 1 condition |
| SAA1serum amyloid A1 | Often (30–79%) | In 1 condition |
| SPINK5serine peptidase inhibitor Kazal type 5 | Often (30–79%) | In 2 conditions |
| TFRCtransferrin receptor | Often (30–79%) | In 1 condition |
| VIPAS39VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | Often (30–79%) | In 1 condition |
| VPS33BVPS33B late endosome and lysosome associated | Often (30–79%) | In 1 condition |
| ADNPactivity dependent neuroprotector homeobox | Sometimes (5–29%) | In 1 condition |
| CARD11caspase recruitment domain family member 11 | Sometimes (5–29%) | In 1 condition |
| CARMIL2capping protein regulator and myosin 1 linker 2 | Sometimes (5–29%) | In 1 condition |
| CCDC47coiled-coil domain containing 47 | Sometimes (5–29%) | In 1 condition |
| COG4component of oligomeric golgi complex 4 | Sometimes (5–29%) | In 1 condition |
| DOCK2dedicator of cytokinesis 2 | Sometimes (5–29%) | In 1 condition |
| GINS3GINS complex subunit 3 | Sometimes (5–29%) | In 1 condition |
| HEATR3HEAT repeat containing 3 | Sometimes (5–29%) | In 1 condition |
| IGHMimmunoglobulin heavy constant mu | Sometimes (5–29%) | In 1 condition |
| IPO8importin 8 | Sometimes (5–29%) | In 1 condition |
| ITCHitchy E3 ubiquitin protein ligase | Sometimes (5–29%) | In 1 condition |
| KMT5Blysine methyltransferase 5B | Sometimes (5–29%) | In 1 condition |
| PGM1phosphoglucomutase 1 | Sometimes (5–29%) | In 1 condition |
| PKP1plakophilin 1 | Sometimes (5–29%) | In 1 condition |
| PPP2R5Dprotein phosphatase 2 regulatory subunit B'delta | Sometimes (5–29%) | In 2 conditions |
| SLC35C1solute carrier family 35 member C1 | Sometimes (5–29%) | In 1 condition |
| SONSON DNA and RNA binding protein | Sometimes (5–29%) | In 2 conditions |
| SREBF1sterol regulatory element binding transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| STAT5Bsignal transducer and activator of transcription 5B | Sometimes (5–29%) | In 1 condition |
| TNFRSF1ATNF receptor superfamily member 1A | Sometimes (5–29%) | In 1 condition |
| USP7ubiquitin specific peptidase 7 | Sometimes (5–29%) | In 1 condition |
| WDR83OSWD repeat domain 83 opposite strand | Sometimes (5–29%) | In 1 condition |
| ASAH1N-acylsphingosine amidohydrolase 1 | Rarely (1–4%) | In 1 condition |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Rarely (1–4%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Not recorded | In 1 condition |
| FOXN1forkhead box N1 | Not recorded | In 1 condition |
| HEXBhexosaminidase subunit beta | Not recorded | In 1 condition |
| IKBKBinhibitor of nuclear factor kappa B kinase subunit beta | Not recorded | In 1 condition |
| RNF113Aring finger protein 113A | Not recorded | In 1 condition |
| TERTtelomerase reverse transcriptase | Not recorded | In 1 condition |
| TKFCtriokinase and FMN cyclase | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.17-8666dff2.
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