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Gene

PCNA

proliferating cell nuclear antigen

Summary

Cytogenetic location
20p12.3
Coordinates
Chromosome 20: 5,114,953–5,119,958 (GRCh38)
Exons
6 exons across 5 kb
Protein
261 amino acids
MANE Select transcript
ENST00000379143.10NM_182649.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PCNA yet. The test sequences your whole genome, so your data includes it all the same.

How PCNA is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 20, with a bracket where PCNA sits. PCNA and 8 genes near it on chromosome 20, from 4,617,456 to 5,617,455.Chromosome 2020p12.3p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.334.8 Mb5 Mb5.2 Mb5.4 Mb5.6 MbPRNP: 4,685,730–4,701,590, forward strandPRNPPRND: 4,721,909–4,728,460, forward strandPRNDRASSF2: 4,780,019–4,823,870, reverse strandRASSF2SLC23A2: 4,851,729–5,010,313, reverse strandSLC23A2TMEM230: 5,068,232–5,113,452, reverse strandTMEM230PCNA: 5,114,953–5,119,958, reverse strandPCNACDS2: 5,126,879–5,197,887, forward strandCDS2PROKR2: 5,298,871–5,316,959, reverse strandPROKR2GPCPD1: 5,544,404–5,611,058, reverse strandGPCPD1Diagram of PCNA: 6 exons on the reverse strand of chromosome 20Exon 4: 1 known disease-causing siteExon 6: 5,114,953–5,115,362, 410 basesExon 5: 5,115,449–5,115,572, 124 basesExon 4: 5,117,470–5,117,664, 195 basesExon 3: 5,118,610–5,118,677, 68 basesExon 2: 5,118,769–5,118,866, 98 basesExon 1: 5,119,578–5,119,958, 381 bases6543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.3 kb of the gene's 5 kb; 786 of those bases code for the protein.

How a genome test reads PCNA

1

position in PCNA where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 5 kb of PCNA, introns included, not only the 1.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PCNA gene: proliferating cell nuclear antigen. Retrieved 16 October 2026, from https://dantelabs.com/genes/pcna

Vancouver

Dante Labs. PCNA gene: proliferating cell nuclear antigen [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/pcna

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