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Gene

CYP2D6

cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)

Summary

Cytogenetic location
22q13.2
Coordinates
Chromosome 22: 42,126,499–42,130,810 (GRCh38)
Exons
9 exons across 4.3 kb
Protein
497 amino acids
Also known as
CPD6, P450-DB1, CYP2D, P450C2D
Previous symbols
CYP2DL1, CYP2D7P2, CYP2D7BP, CYP2D8P2, CYP2D7AP
MANE Select transcript
ENST00000645361.2NM_000106.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads CYP2D6 yet. The test sequences your whole genome, so your data includes it all the same.

How CYP2D6 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 22, with a bracket where CYP2D6 sits. CYP2D6 and 24 genes near it on chromosome 22, from 41,628,655 to 42,628,654.Chromosome 2222q13.2p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3341.8 Mb42 Mb42.2 Mb42.4 Mb42.6 MbXRCC6: 41,620,786–41,664,087, forward strandXRCC6SNU13: 41,666,627–41,690,504, reverse strandSNU13MEI1: 41,699,494–41,799,456, forward strandMEI1CCDC134: 41,800,321–41,832,178, forward strandCCDC134SREBF2: 41,833,029–41,907,308, forward strandSREBF2SHISA8: 41,906,316–41,915,129, reverse strandSHISA8TNFRSF13C: 41,922,032–41,926,806, reverse strandTNFRSF13CCENPM: 41,927,514–41,947,183, reverse strandCENPMSMIM45: 41,947,178–41,958,942, forward strandSMIM45SEPTIN3: 41,969,443–41,998,221, forward strandSEPTIN3WBP2NL: 41,998,725–42,058,456, forward strandNAGA: 42,032,595–42,071,198, reverse strandNAGAPHETA2: 42,073,789–42,079,439, forward strandPHETA2SMDT1: 42,079,564–42,090,033, forward strandSMDT1NDUFA6: 42,080,336–42,090,884, reverse strandNDUFA6CYP2D6: 42,126,499–42,130,810, reverse strandCYP2D6CYP2D7: 42,140,203–42,149,500, reverse strandCYP2D7TCF20: 42,160,013–42,343,616, reverse strandTCF20NFAM1: 42,380,407–42,432,425, reverse strandNFAM1RRP7A: 42,507,982–42,519,853, reverse strandRRP7ASERHL2: 42,553,617–42,574,387, forward strandSERHL2POLDIP3: 42,582,750–42,614,962, reverse strandPOLDIP3: 42,583,836–42,627,688, reverse strandRNU12: 42,615,244–42,615,393, forward strandRNU12CYB5R3: 42,615,730–42,720,870, reverse strandDiagram of CYP2D6: 9 exons on the reverse strand of chromosome 22Exon 9: 42,126,499–42,126,752, 254 basesExon 8: 42,126,851–42,126,992, 142 basesExon 7: 42,127,447–42,127,634, 188 basesExon 6: 42,127,842–42,127,983, 142 basesExon 5: 42,128,174–42,128,350, 177 basesExon 4: 42,128,784–42,128,944, 161 basesExon 3: 42,129,033–42,129,185, 153 basesExon 2: 42,129,738–42,129,909, 172 basesExon 1: 42,130,612–42,130,810, 199 bases9876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.6 kb of the gene's 4.3 kb; 1,494 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). CYP2D6 gene: cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene). Retrieved 16 October 2026, from https://dantelabs.com/genes/cyp2d6

Vancouver

Dante Labs. CYP2D6 gene: cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene) [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cyp2d6

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