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Gene

ZBTB24

zinc finger and BTB domain containing 24

Summary

Cytogenetic location
6q21
Coordinates
Chromosome 6: 109,462,594–109,483,219 (GRCh38)
Exons
7 exons across 20.6 kb
Protein
697 amino acids
Also known as
KIAA0441, BIF1, PATZ2
Previous symbols
ZNF450
MANE Select transcript
ENST00000230122.4NM_014797.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Dyskeratosis Congenita

    • Telomere syndromes

      Disorders of short telomeres caused by variants in telomere-maintenance genes such as TERT, TERC, RTEL1 and PARN, which can cause bone marrow failure, lung fibrosis and liver disease even without classic skin signs.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Monitoring of blood counts, lungs and liver is advised, and the diagnosis informs donor selection and treatment choices for stem cell transplantation.

How ZBTB24 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where ZBTB24 sits. ZBTB24 and 9 genes near it on chromosome 6, from 108,972,907 to 109,972,906.Chromosome 66q21p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27109 Mb109.2 Mb109.4 Mb109.6 Mb109.8 MbARMC2: 108,841,937–108,974,551, forward strandARMC2SESN1: 108,984,309–109,095,097, reverse strandSESN1CEP57L1: 109,095,105–109,174,418, forward strandCEP57L1CD164: 109,307,627–109,382,536, reverse strandCD164PPIL6: 109,390,215–109,441,171, reverse strandPPIL6SMPD2: 109,440,678–109,446,515, forward strandSMPD2MICAL1: 109,444,062–109,465,968, reverse strandMICAL1ZBTB24: 109,462,594–109,483,219, reverse strandZBTB24AK9: 109,492,855–109,691,229, reverse strandAK9FIG4: 109,690,609–109,878,098, forward strandFIG4Diagram of ZBTB24: 7 exons on the reverse strand of chromosome 6Exon 7: 5 known disease-causing sitesExon 6: 1 known disease-causing siteExon 5: 2 known disease-causing sitesExon 4: 4 known disease-causing sitesExon 3: 6 known disease-causing sitesExon 2: 25 known disease-causing sitesExon 7: 109,462,594–109,466,574, 3,981 basesExon 6: 109,467,653–109,467,734, 82 basesExon 5: 109,475,399–109,475,482, 84 basesExon 4: 109,476,175–109,476,258, 84 basesExon 3: 109,476,763–109,476,930, 168 basesExon 2: 109,481,075–109,482,054, 980 basesExon 1: 109,483,098–109,483,219, 122 bases76543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.5 kb of the gene's 20.6 kb; 2,094 of those bases code for the protein.

How a genome test reads ZBTB24

49

positions in ZBTB24 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 20.6 kb of ZBTB24, introns included, not only the 5.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ZBTB24 gene: zinc finger and BTB domain containing 24. Retrieved 17 October 2026, from https://dantelabs.com/genes/zbtb24

Vancouver

Dante Labs. ZBTB24 gene: zinc finger and BTB domain containing 24 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/zbtb24

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