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Gene

RFX6

regulatory factor X6

Summary

Cytogenetic location
6q22.1
Coordinates
Chromosome 6: 116,877,242–116,932,161 (GRCh38)
Exons
19 exons across 54.9 kb
Protein
928 amino acids
Also known as
MGC33442, dJ955L16.1
Previous symbols
RFXDC1
MANE Select transcript
ENST00000332958.3NM_173560.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Diabetes Mellitus

    • A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.

      • ClinGen rates the link definitive
      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Teplizumab (Tzield) for stage 2 presymptomatic T1D (FDA approved 2022); insulin replacement at clinical T1D onset; TrialNet autoantibody screening for high-risk relatives; closed-loop insulin delivery systems

How RFX6 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where RFX6 sits. RFX6 and 15 genes near it on chromosome 6, from 116,404,702 to 117,404,701.Chromosome 66q22.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27116.6 Mb116.8 Mb117 Mb117.2 Mb117.4 MbDSE: 116,253,604–116,444,861, forward strandDSE: 116,399,395–116,463,696, forward strandCALHM6: 116,461,365–116,466,082, forward strandCALHM6TRAPPC3L: 116,494,989–116,545,684, reverse strandTRAPPC3LCALHM5: 116,511,604–116,524,788, forward strandCALHM5CALHM4: 116,529,013–116,561,127, forward strandCALHM4RWDD1: 116,571,386–116,598,204, forward strandRWDD1RSPH4A: 116,616,474–116,634,765, forward strandRSPH4AZUP1: 116,635,616–116,668,816, reverse strandZUP1KPNA5: 116,681,149–116,741,867, forward strandKPNA5FAM162B: 116,724,567–116,765,833, reverse strandFAM162BGPRC6A: 116,792,085–116,829,083, reverse strandGPRC6ARFX6: 116,877,242–116,932,161, forward strandRFX6VGLL2: 117,265,558–117,276,512, forward strandVGLL2ROS1: 117,287,353–117,425,946, reverse strandROS1: 117,318,211–117,573,571, reverse strandDiagram of RFX6: 19 exons on the forward strand of chromosome 6Exon 1: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 11: 2 known disease-causing sitesExon 12: 2 known disease-causing sitesExon 13: 1 known disease-causing siteExon 17: 1 known disease-causing siteExon 1: 116,877,242–116,877,498, 257 basesExon 2: 116,877,796–116,877,952, 157 basesExon 3: 116,880,544–116,880,667, 124 basesExon 4: 116,882,367–116,882,428, 62 basesExon 5: 116,893,987–116,894,064, 78 basesExon 6: 116,895,180–116,895,207, 28 basesExon 7: 116,910,935–116,911,042, 108 basesExon 8: 116,916,008–116,916,085, 78 basesExon 9: 116,916,201–116,916,314, 114 basesExon 10: 116,918,037–116,918,086, 50 basesExon 11: 116,919,137–116,919,296, 160 basesExon 12: 116,920,310–116,920,454, 145 basesExon 13: 116,922,042–116,922,151, 110 basesExon 14: 116,923,107–116,923,224, 118 basesExon 15: 116,924,669–116,924,791, 123 basesExon 16: 116,925,453–116,925,659, 207 basesExon 17: 116,927,027–116,927,539, 513 basesExon 18: 116,928,759–116,928,971, 213 basesExon 19: 116,931,331–116,932,161, 831 bases151015195′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.5 kb of the gene's 54.9 kb; 2,787 of those bases code for the protein.

How a genome test reads RFX6

11

positions in RFX6 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 54.9 kb of RFX6, introns included, not only the 3.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RFX6 gene: regulatory factor X6. Retrieved 17 October 2026, from https://dantelabs.com/genes/rfx6

Vancouver

Dante Labs. RFX6 gene: regulatory factor X6 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rfx6

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