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Gene

NEUROG3

neurogenin 3

Summary

Cytogenetic location
10q22.1
Coordinates
Chromosome 10: 69,571,698–69,573,422 (GRCh38)
Exons
2 exons across 1.7 kb
Protein
214 amino acids
Also known as
Atoh5, Math4B, ngn3, bHLHa7
MANE Select transcript
ENST00000242462.5NM_020999.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Congenital Diarrhoeas & Enteropathies

    • Congenital diarrhoea

      Inherited conditions, including congenital chloride diarrhoea (SLC26A3), microvillus inclusion disease (MYO5B), tufting enteropathy (EPCAM) and congenital sodium diarrhoea (SPINT2, SLC9A3), that cause chronic diarrhoea from early infancy.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      A specific diagnosis directs treatment such as electrolyte replacement for chloride diarrhoea, or early planning for parenteral nutrition or intestinal transplant in microvillus inclusion disease and tufting enteropathy.

  • Diabetes Mellitus

    • A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Teplizumab (Tzield) for stage 2 presymptomatic T1D (FDA approved 2022); insulin replacement at clinical T1D onset; TrialNet autoantibody screening for high-risk relatives; closed-loop insulin delivery systems

  • Neonatal Diabetes Mellitus

    • Diabetes diagnosed in the first months of life, either permanent or transient, caused by single-gene defects in insulin production or secretion.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Most people with KCNJ11 or ABCC8 neonatal diabetes can switch from insulin injections to sulfonylurea tablets, often with better glucose control.

How NEUROG3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 10, with a bracket where NEUROG3 sits. NEUROG3 and 11 genes near it on chromosome 10, from 69,072,560 to 70,072,559.Chromosome 1010q22.1p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.369.2 Mb69.4 Mb69.6 Mb69.8 Mb70 MbSRGN: 69,087,579–69,105,696, forward strandSRGNVPS26A: 69,123,512–69,174,412, forward strandVPS26ASUPV3L1: 69,180,234–69,209,108, forward strandSUPV3L1HKDC1: 69,220,292–69,267,569, forward strandHKDC1HK1: 69,269,984–69,403,497, forward strandHK1TACR2: 69,402,885–69,416,923, reverse strandTACR2TSPAN15: 69,451,150–69,507,676, forward strandTSPAN15NEUROG3: 69,571,698–69,573,422, reverse strandNEUROG3FAM241B: 69,630,228–69,633,614, forward strandFAM241BCOL13A1: 69,801,875–69,964,275, forward strandCOL13A1MACROH2A2: 70,052,544–70,112,282, forward strandMACROH2A2AIFM2: 70,054,661–70,133,269, reverse strandAIFM2Diagram of NEUROG3: 2 exons on the reverse strand of chromosome 10Exon 2: 7 known disease-causing sitesExon 2: 69,571,698–69,573,044, 1,347 basesExon 1: 69,573,210–69,573,422, 213 bases215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.6 kb of the gene's 1.7 kb; 645 of those bases code for the protein.

How a genome test reads NEUROG3

7

positions in NEUROG3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 1.7 kb of NEUROG3, introns included, not only the 1.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NEUROG3 gene: neurogenin 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/neurog3

Vancouver

Dante Labs. NEUROG3 gene: neurogenin 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/neurog3

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