Traits

Traits linked to CDK19

cyclin dependent kinase 19

The Human Phenotype Ontology links 64 traits to CDK19, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	Cât de frecvent apare
Epilepsy	Întotdeauna
Global developmental delay	Întotdeauna
Intellectual disability	Întotdeauna
Encephalopathy	Foarte des (80–99%)
Abnormality of coordination	Des (30–79%)
Decreased reflex response	Des (30–79%)
Degeneration of cerebrum	Des (30–79%)
Delayed CNS myelination	Des (30–79%)
Delayed speech and language development	Des (30–79%)
EEG with multifocal slow activity	Des (30–79%)
Infantile spasms	Des (30–79%)
Loss of developmental milestones	Des (30–79%)
Abnormal corpus callosum morphology	Uneori (5–29%)
Abnormal gait	Uneori (5–29%)
Abnormal myelination	Uneori (5–29%)
Ataxia	Uneori (5–29%)
Attention deficit	Uneori (5–29%)
Autism	Uneori (5–29%)
Behavioral abnormality	Uneori (5–29%)
Brain degeneration	Uneori (5–29%)
Diminished deep tendon reflex	Uneori (5–29%)
Disorder of involuntary muscle movements	Uneori (5–29%)
Hypsarrhythmia	Uneori (5–29%)
Impulsivity	Uneori (5–29%)
Involuntary movements	Uneori (5–29%)
Jerking	Uneori (5–29%)
Mental deterioration	Uneori (5–29%)
Tremor	Uneori (5–29%)
Unsteady walk	Uneori (5–29%)
Repeated seizures without recovery between them	Rar (1–4%)
Recurrent hand flapping	Neînregistrat

Abnormality of head or neck

Trait	Cât de frecvent apare
Bulbous nose	Întotdeauna
Prominent nose	Întotdeauna
Wide mouth	Întotdeauna
Widely spaced teeth	Întotdeauna
Carp-like mouth	Des (30–79%)
High palate	Des (30–79%)
Horizontal eyebrow	Des (30–79%)
Midface retrusion	Des (30–79%)
Abnormally small head	Uneori (5–29%)
Downward slanting of the opening between the eyelids	Uneori (5–29%)
Failure of development of between one and six teeth	Uneori (5–29%)
High forehead	Uneori (5–29%)

Abnormality of the eye

Trait	Cât de frecvent apare
Abnormally close eyes	Des (30–79%)
Wide-set eyes	Des (30–79%)
Drooping upper eyelid	Uneori (5–29%)
Involuntary, rapid, rhythmic eye movements	Uneori (5–29%)
Abnormal involuntary eye movements	Rar (1–4%)
Abnormality of vision	Rar (1–4%)
Optic atrophy	Rar (1–4%)
Retina degeneration	Rar (1–4%)

Abnormality of the musculoskeletal system

Trait	Cât de frecvent apare
Spasticity and rigidity of muscles	Întotdeauna
Generalized decreased muscle tone	Des (30–79%)
Scoliosis	Des (30–79%)
Involuntary muscle stiffness, contraction, or spasm	Uneori (5–29%)
Poor head control	Uneori (5–29%)
Rigidity	Uneori (5–29%)

Abnormality of limbs

Trait	Cât de frecvent apare
Increased muscle tone of arm or leg	Rar (1–4%)
Single transverse palmar crease	Neînregistrat

Abnormality of the digestive system

Trait	Cât de frecvent apare
Acid reflux	Uneori (5–29%)
Feeding difficulties	Uneori (5–29%)

Growth abnormality

Trait	Cât de frecvent apare
Faltering weight	Des (30–79%)
Short stature	Uneori (5–29%)

Abnormality of prenatal development or birth

Trait	Cât de frecvent apare
Less than 10 fetal movements in 12 hours	Uneori (5–29%)

Cât de frecvent apare în rândul persoanelor cu una dintre afecțiunile asociate genei, cel mai des întâlnit dintre acestea, conform Human Phenotype Ontology. Aceste pagini descriu trăsături și cercetările din spatele lor; ele nu reprezintă un diagnostic, iar pentru simptome trebuie să vă adresați medicului sau consilierului genetic.

De unde provin aceste informații

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CDK19 and how often each is seen. Find out more at hpo.jax.org.

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