Traits

Traits linked to CDK19

cyclin dependent kinase 19

The Human Phenotype Ontology links 64 traits to CDK19, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	Kaip dažnai pasireiškia
Epilepsy	Visada
Global developmental delay	Visada
Intellectual disability	Visada
Encephalopathy	Labai dažnai (80–99%)
Abnormality of coordination	Dažnai (30–79%)
Decreased reflex response	Dažnai (30–79%)
Degeneration of cerebrum	Dažnai (30–79%)
Delayed CNS myelination	Dažnai (30–79%)
Delayed speech and language development	Dažnai (30–79%)
EEG with multifocal slow activity	Dažnai (30–79%)
Infantile spasms	Dažnai (30–79%)
Loss of developmental milestones	Dažnai (30–79%)
Abnormal corpus callosum morphology	Kartais (5–29%)
Abnormal gait	Kartais (5–29%)
Abnormal myelination	Kartais (5–29%)
Ataxia	Kartais (5–29%)
Attention deficit	Kartais (5–29%)
Autism	Kartais (5–29%)
Behavioral abnormality	Kartais (5–29%)
Brain degeneration	Kartais (5–29%)
Diminished deep tendon reflex	Kartais (5–29%)
Disorder of involuntary muscle movements	Kartais (5–29%)
Hypsarrhythmia	Kartais (5–29%)
Impulsivity	Kartais (5–29%)
Involuntary movements	Kartais (5–29%)
Jerking	Kartais (5–29%)
Mental deterioration	Kartais (5–29%)
Tremor	Kartais (5–29%)
Unsteady walk	Kartais (5–29%)
Repeated seizures without recovery between them	Retai (1–4 %)
Recurrent hand flapping	Neužfiksuota

Abnormality of head or neck

Trait	Kaip dažnai pasireiškia
Bulbous nose	Visada
Prominent nose	Visada
Wide mouth	Visada
Widely spaced teeth	Visada
Carp-like mouth	Dažnai (30–79%)
High palate	Dažnai (30–79%)
Horizontal eyebrow	Dažnai (30–79%)
Midface retrusion	Dažnai (30–79%)
Abnormally small head	Kartais (5–29%)
Downward slanting of the opening between the eyelids	Kartais (5–29%)
Failure of development of between one and six teeth	Kartais (5–29%)
High forehead	Kartais (5–29%)

Abnormality of the eye

Trait	Kaip dažnai pasireiškia
Abnormally close eyes	Dažnai (30–79%)
Wide-set eyes	Dažnai (30–79%)
Drooping upper eyelid	Kartais (5–29%)
Involuntary, rapid, rhythmic eye movements	Kartais (5–29%)
Abnormal involuntary eye movements	Retai (1–4 %)
Abnormality of vision	Retai (1–4 %)
Optic atrophy	Retai (1–4 %)
Retina degeneration	Retai (1–4 %)

Abnormality of the musculoskeletal system

Trait	Kaip dažnai pasireiškia
Spasticity and rigidity of muscles	Visada
Generalized decreased muscle tone	Dažnai (30–79%)
Scoliosis	Dažnai (30–79%)
Involuntary muscle stiffness, contraction, or spasm	Kartais (5–29%)
Poor head control	Kartais (5–29%)
Rigidity	Kartais (5–29%)

Abnormality of limbs

Trait	Kaip dažnai pasireiškia
Increased muscle tone of arm or leg	Retai (1–4 %)
Single transverse palmar crease	Neužfiksuota

Abnormality of the digestive system

Trait	Kaip dažnai pasireiškia
Acid reflux	Kartais (5–29%)
Feeding difficulties	Kartais (5–29%)

Growth abnormality

Trait	Kaip dažnai pasireiškia
Faltering weight	Dažnai (30–79%)
Short stature	Kartais (5–29%)

Abnormality of prenatal development or birth

Trait	Kaip dažnai pasireiškia
Less than 10 fetal movements in 12 hours	Kartais (5–29%)

Kaip dažnai šis požymis pasitaiko žmonėms, turintiems vieną iš geno sukeliamų ligų, ir kuris dažnis tarp jų didžiausias, pagal Žmogaus fenotipo ontologijos duomenis. Šiuose puslapiuose aprašomi požymiai ir juos grindžiantys tyrimai; tai nėra diagnozė, o su simptomais kreipkitės į gydytoją ar genetikos konsultantą.

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The Human Phenotype Ontology, release 2026-09-01: the traits linked to CDK19 and how often each is seen. Find out more at hpo.jax.org.

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