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Gene

NACC1

nucleus accumbens associated 1

Summary

Cytogenetic location
19p13.13
Coordinates
Chromosome 19: 13,118,264–13,141,147 (GRCh38)
Exons
6 exons across 22.9 kb
Protein
527 amino acids
Also known as
NAC1, NAC-1, BEND8, BTBD30
Previous symbols
BTBD14B
MANE Select transcript
ENST00000292431.5NM_052876.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • 4 GenCC submitters rate it definitive or strong

    • Intellectual Disability

      • One of 233 genes linked to it

        • ClinGen rates the link definitive
        • 1 GenCC submitter rates it definitive or strong

    How NACC1 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 19, with a bracket where NACC1 sits. NACC1 and 37 genes near it on chromosome 19, from 12,629,706 to 13,629,705.Chromosome 1919p13.13p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4312.8 Mb13 Mb13.2 Mb13.4 Mb13.6 MbZNF490: 12,575,832–12,640,098, reverse strandZNF791: 12,610,916–12,633,840, forward strandZNF791MAN2B1: 12,643,831–12,666,762, reverse strand: 12,643,831–12,648,397, reverse strand: 12,664,828–12,669,397, reverse strandWDR83: 12,666,802–12,675,832, forward strandWDR83OS: 12,668,065–12,669,467, reverse strand: 12,668,071–12,681,834, reverse strandDHPS: 12,673,411–12,681,901, reverse strandDHPSFBXW9: 12,687,801–12,696,659, reverse strandFBXW9GNG14: 12,687,998–12,688,422, forward strandGNG14TNPO2: 12,699,111–12,724,011, reverse strandTNPO2TRIR: 12,730,640–12,734,747, reverse strandTRIRGET3: 12,737,139–12,748,325, forward strandGET3BEST2: 12,751,673–12,758,458, forward strandBEST2HOOK2: 12,762,640–12,872,740, reverse strandHOOK2JUNB: 12,791,486–12,793,315, forward strandPRDX2: 12,796,817–12,801,882, reverse strandTHSD8: 12,802,031–12,813,581, forward strandRNASEH2A: 12,806,505–12,813,644, forward strandRNASEH2ARTBDN: 12,825,477–12,838,362, reverse strandRTBDNMAST1: 12,833,860–12,874,952, forward strandMAST1DNASE2: 12,875,209–12,881,595, reverse strandKLF1: 12,884,405–12,887,201, reverse strandKLF1GCDH: 12,891,128–12,915,261, forward strandSYCE2: 12,898,786–12,919,306, reverse strandFARSA: 12,921,138–12,934,037, reverse strandCALR: 12,938,578–12,944,525, forward strandCALRRAD23A: 12,945,716–12,953,646, forward strandRAD23AGADD45GIP1: 12,950,701–12,957,333, reverse strandGADD45GIP1DAND5: 12,965,159–12,974,760, forward strandDAND5NFIX: 12,995,401–13,098,796, forward strandNFIXLYL1: 13,099,028–13,103,188, reverse strandLYL1TRMT1: 13,104,899–13,117,567, reverse strandTRMT1NACC1: 13,118,264–13,141,147, forward strandNACC1STX10: 13,144,058–13,150,383, reverse strandSTX10IER2: 13,150,403–13,156,981, forward strandIER2CACNA1A: 13,206,442–13,624,489, reverse strandCACNA1ADiagram of NACC1: 6 exons on the forward strand of chromosome 19Exon 2: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 1: 13,118,264–13,118,454, 191 basesExon 2: 13,135,200–13,136,153, 954 basesExon 3: 13,136,232–13,136,405, 174 basesExon 4: 13,137,271–13,137,376, 106 basesExon 5: 13,137,478–13,137,575, 98 basesExon 6: 13,138,147–13,141,147, 3,001 bases12465′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 4.5 kb of the gene's 22.9 kb; 1,584 of those bases code for the protein.

    How a genome test reads NACC1

    2

    positions in NACC1 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 22.9 kb of NACC1, introns included, not only the 4.5 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). NACC1 gene: nucleus accumbens associated 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/nacc1

    Vancouver

    Dante Labs. NACC1 gene: nucleus accumbens associated 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/nacc1

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