Skip to content
Use your HSA or FSA funds

Trait

Extra heart beat

Clinical name: Premature ventricular contraction

Premature ventricular contractions (PVC) or ventricular extrasystoles are premature contractions of the heart that arise in response to an impulse in the ventricles rather than the normal impulse from the sinoatrial (SA) node.

HPO HP:0006682

Summary

Also called
Missed heartbeat, Skipped heartbeat, Premature ventricular beat, Premature ventricular contractions, Ventricular ectopics, Ventricular extrasystoles, Ventricular premature beat
Body system
Abnormality of the cardiovascular system

31 genes linked to Extra heart beat

Changes in these genes cause rare conditions in which Extra heart beat is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
CALM1calmodulin 1AlwaysIn 1 condition
CNBPCCHC-type zinc finger nucleic acid binding proteinAlwaysIn 1 condition
DEPDC5DEP domain containing 5, GATOR1 subcomplex subunitAlwaysIn 1 condition
EMDemerinAlwaysIn 1 condition
KCNE1potassium voltage-gated channel subfamily E regulatory subunit 1AlwaysIn 1 condition
TECRLtrans-2,3-enoyl-CoA reductase likeAlwaysIn 1 condition
TRDNtriadinAlwaysIn 1 condition
JUPjunction plakoglobinVery often (80–99%)In 1 condition
CALM2calmodulin 2Often (30–79%)In 1 condition
DSG2desmoglein 2Often (30–79%)In 1 condition
DSPdesmoplakinOften (30–79%)In 1 condition
MYZAPmyocardial zonula adherens proteinOften (30–79%)In 1 condition
PKP2plakophilin 2Often (30–79%)In 1 condition
TOR1AIP1torsin 1A interacting protein 1Often (30–79%)In 1 condition
ALPK3alpha kinase 3Sometimes (5–29%)In 1 condition
CACNA1Scalcium voltage-gated channel subunit alpha1 SSometimes (5–29%)In 1 condition
CDH2cadherin 2Sometimes (5–29%)In 1 condition
DOHHdeoxyhypusine hydroxylaseSometimes (5–29%)In 1 condition
KCNJ2potassium inwardly rectifying channel subfamily J member 2Sometimes (5–29%)In 1 condition
KCNJ5potassium inwardly rectifying channel subfamily J member 5Sometimes (5–29%)In 1 condition
NFIXnuclear factor I XSometimes (5–29%)In 1 condition
POPDC2popeye domain cAMP effector 2Sometimes (5–29%)In 1 condition
RYR1ryanodine receptor 1Sometimes (5–29%)In 1 condition
TANGO2transport and golgi organization 2 homologSometimes (5–29%)In 1 condition
VEZF1vascular endothelial zinc finger 1Sometimes (5–29%)In 1 condition
SCN5Asodium voltage-gated channel alpha subunit 5Rarely (1–4%)In 1 condition
DPP6dipeptidyl peptidase like 6Not recordedIn 1 condition
NAA10N-alpha-acetyltransferase 10, NatA catalytic subunitNot recordedIn 1 condition
SLC25A20solute carrier family 25 member 20Not recordedIn 1 condition
TMEM43transmembrane protein 43Not recordedIn 1 condition
TNNI3KTNNI3 interacting kinaseNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Ventricular arrhythmia

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test