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Gene

RORC

RAR related orphan receptor C

Summary

Cytogenetic location
1q21.3
Coordinates
Chromosome 1: 151,806,071–151,831,802 (GRCh38)
Exons
11 exons across 25.7 kb
Protein
518 amino acids
Also known as
RZRG, RORG, NR1F3, TOR
MANE Select transcript
ENST00000318247.7NM_005060.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Mendelian Susceptibility to Mycobacterial Disease (MSMD)

    • Mendelian susceptibility to mycobacterial disease

      Inherited defects in the IL-12/interferon-gamma pathway, caused by genes such as IL12RB1, IL12B, IFNGR1, IFNGR2, STAT1, IRF8, ISG15 and RORC.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Affected people and at-risk relatives should avoid BCG and other live vaccines, infections need prolonged treatment, and some forms respond to interferon-gamma.

How RORC is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where RORC sits. RORC and 24 genes near it on chromosome 1, from 151,318,937 to 152,318,936.Chromosome 11q21.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44151.4 Mb151.6 Mb151.8 Mb152 Mb152.2 MbPI4KB: 151,291,792–151,328,394, reverse strandPI4KBRFX5: 151,340,640–151,347,339, reverse strandRFX5SELENBP1: 151,364,157–151,372,716, reverse strandSELENBP1PSMB4: 151,399,556–151,401,941, forward strandPSMB4POGZ: 151,402,724–151,459,511, reverse strandPOGZCGN: 151,510,139–151,538,692, forward strandCGNTUFT1: 151,540,305–151,583,583, forward strandTUFT1SNX27: 151,611,985–151,699,091, forward strandSNX27CELF3: 151,700,058–151,716,803, reverse strandCELF3RIIAD1: 151,710,433–151,729,805, forward strandRIIAD1MRPL9: 151,759,643–151,763,522, reverse strandMRPL9OAZ3: 151,762,899–151,771,334, forward strandOAZ3TDRKH: 151,769,799–151,791,416, reverse strandTDRKHLINGO4: 151,800,264–151,805,419, reverse strandLINGO4RORC: 151,806,071–151,831,802, reverse strandRORCC2CD4D: 151,837,818–151,840,557, reverse strandC2CD4DTHEM5: 151,847,101–151,853,712, reverse strandTHEM5THEM4: 151,870,866–151,909,879, reverse strandTHEM4S100A10: 151,981,697–151,993,891, reverse strandS100A10S100A11: 152,032,504–152,047,907, reverse strandS100A11TCHHL1: 152,084,141–152,089,064, reverse strandTCHHL1TCHH: 152,106,317–152,115,444, reverse strandTCHHRPTN: 152,153,595–152,159,228, reverse strandRPTNHRNR: 152,212,076–152,224,193, reverse strandHRNRFLG: 152,302,165–152,325,239, reverse strandFLGDiagram of RORC: 11 exons on the reverse strand of chromosome 1Exon 8: 1 known disease-causing siteExon 7: 2 known disease-causing sitesExon 6: 1 known disease-causing siteExon 5: 2 known disease-causing sitesExon 4: 2 known disease-causing sitesExon 11: 151,806,071–151,807,633, 1,563 basesExon 10: 151,811,325–151,811,434, 110 basesExon 9: 151,812,947–151,813,057, 111 basesExon 8: 151,813,239–151,813,346, 108 basesExon 7: 151,813,488–151,813,620, 133 basesExon 6: 151,814,574–151,814,695, 122 basesExon 5: 151,814,913–151,815,425, 513 basesExon 4: 151,816,664–151,816,805, 142 basesExon 3: 151,817,195–151,817,280, 86 basesExon 2: 151,829,429–151,829,458, 30 basesExon 1: 151,831,725–151,831,802, 78 bases1110864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3 kb of the gene's 25.7 kb; 1,557 of those bases code for the protein.

How a genome test reads RORC

9

positions in RORC where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 25.7 kb of RORC, introns included, not only the 3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RORC gene: RAR related orphan receptor C. Retrieved 17 October 2026, from https://dantelabs.com/genes/rorc

Vancouver

Dante Labs. RORC gene: RAR related orphan receptor C [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rorc

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