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Gene

IGFALS

insulin like growth factor binding protein acid labile subunit

Summary

Cytogenetic location
16p13.3
Coordinates
Chromosome 16: 1,790,413–1,793,705 (GRCh38)
Exons
2 exons across 3.3 kb
Protein
605 amino acids
Also known as
ALS
MANE Select transcript
ENST00000215539.4NM_004970.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Growth Hormone Insensitivity & IGF-1 Axis Disorders

    • Growth hormone insensitivity syndrome

      Short stature with normal or high growth hormone but low IGF-1, including Laron syndrome (GHR), IGF1, IGFALS and IGF1R defects, and STAT5B deficiency with immune dysregulation.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Recombinant IGF-1 (mecasermin) can improve growth in some forms; STAT5B deficiency also needs immune and lung follow-up.

How IGFALS is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 16, with a bracket where IGFALS sits. IGFALS and 52 genes near it on chromosome 16, from 1,292,059 to 2,292,058.Chromosome 1616p13.3p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.31.4 Mb1.6 Mb1.8 Mb2 Mb2.2 MbUBE2I: 1,291,357–1,327,018, forward strandUBE2IBAIAP3: 1,333,638–1,349,439, forward strandBAIAP3TSR3: 1,349,236–1,351,898, reverse strandTSR3GNPTG: 1,351,924–1,365,737, forward strandGNPTGUNKL: 1,363,205–1,414,751, reverse strandUNKLUQCC4: 1,419,752–1,420,756, reverse strandUQCC4PERCC1: 1,431,078–1,434,441, forward strandPERCC1CCDC154: 1,434,383–1,444,556, reverse strandCCDC154CLCN7: 1,444,934–1,475,104, reverse strandCLCN7PTX4: 1,485,886–1,488,981, reverse strandPTX4TELO2: 1,493,329–1,512,551, forward strandTELO2IFT140: 1,510,427–1,612,082, reverse strandIFT140TMEM204: 1,528,674–1,555,580, forward strandTMEM204CRAMP1: 1,612,337–1,677,908, forward strandCRAMP1: 1,632,259–1,686,715, forward strandJPT2: 1,678,256–1,702,859, forward strandJPT2MAPK8IP3: 1,706,166–1,770,374, forward strandNME3: 1,770,317–1,771,746, reverse strandMRPS34: 1,771,889–1,773,487, reverse strandEME2: 1,772,283–1,781,708, forward strandEME2SPSB3: 1,776,710–1,793,700, reverse strandSPSB3NUBP2: 1,782,932–1,789,189, forward strandNUBP2IGFALS: 1,790,413–1,793,705, reverse strandIGFALSHAGH: 1,795,620–1,827,187, reverse strandFAHD1: 1,826,967–1,842,053, forward strandMEIOB: 1,833,986–1,884,294, reverse strandMEIOBHS3ST6: 1,911,475–1,918,415, reverse strandHS3ST6MSRB1: 1,935,685–1,943,270, reverse strandMSRB1RPL3L: 1,943,791–1,957,606, reverse strandRPL3LNDUFB10: 1,959,500–1,962,105, forward strandNDUFB10RPS2: 1,961,987–1,965,510, reverse strandRNF151: 1,966,823–1,968,975, forward strandTBL3: 1,971,972–1,983,056, forward strandNOXO1: 1,978,912–1,984,636, reverse strandGFER: 1,983,699–1,987,749, forward strandSYNGR3: 1,989,637–1,994,275, forward strandZNF598: 1,997,654–2,009,821, reverse strandNPW: 2,009,926–2,020,755, forward strandNPWNHERF2: 2,025,356–2,039,026, forward strandNHERF2NTHL1: 2,039,814–2,047,866, reverse strandNTHL1TSC2: 2,047,345–2,089,491, forward strandTSC2PKD1: 2,088,708–2,135,898, reverse strandPKD1RAB26: 2,140,803–2,154,165, forward strandRAB26TRAF7: 2,155,692–2,178,129, forward strandTRAF7CASKIN1: 2,177,180–2,196,788, reverse strandCASKIN1MLST8: 2,204,248–2,209,453, forward strandMLST8BRICD5: 2,209,252–2,210,905, reverse strandBRICD5PGP: 2,211,593–2,214,846, reverse strandPGPE4F1: 2,223,440–2,235,743, forward strandDNASE1L2: 2,235,816–2,238,711, forward strandECI1: 2,239,376–2,252,300, reverse strandRNPS1: 2,253,116–2,268,413, reverse strandRNPS1ABCA3: 2,275,878–2,340,788, reverse strandABCA3Diagram of IGFALS: 2 exons on the reverse strand of chromosome 16Exon 2: 3 known disease-causing sitesExon 1: 1 known disease-causing siteExon 2: 1,790,413–1,792,401, 1,989 basesExon 1: 1,793,637–1,793,705, 69 bases215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.1 kb of the gene's 3.3 kb; 1,818 of those bases code for the protein.

How a genome test reads IGFALS

4

positions in IGFALS where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 3.3 kb of IGFALS, introns included, not only the 2.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). IGFALS gene: insulin like growth factor binding protein acid labile subunit. Retrieved 16 October 2026, from https://dantelabs.com/genes/igfals

Vancouver

Dante Labs. IGFALS gene: insulin like growth factor binding protein acid labile subunit [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/igfals

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