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Gene

PSMC3IP

PSMC3 interacting protein

Summary

Cytogenetic location
17q21.2
Coordinates
Chromosome 17: 42,572,310–42,577,729 (GRCh38)
Exons
8 exons across 5.4 kb
Protein
217 amino acids
Also known as
TBPIP, GT198, HUMGT198A, Hop2
MANE Select transcript
ENST00000393795.8NM_016556.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Female Infertility

    • Diminished or absent ability of a female to achieve conception.

      • 2 GenCC submitters rate it definitive or strong

How PSMC3IP is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where PSMC3IP sits. PSMC3IP and 44 genes near it on chromosome 17, from 42,075,020 to 43,075,019.Chromosome 1717q21.2p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.342.2 Mb42.4 Mb42.6 Mb42.8 Mb43 MbZNF385C: 42,025,576–42,098,479, reverse strandDHX58: 42,101,404–42,112,735, reverse strandKAT2A: 42,113,109–42,121,382, reverse strand: 42,119,674–42,154,916, reverse strandHSPB9: 42,122,804–42,123,352, forward strandHSPB9RAB5C: 42,124,976–42,155,044, reverse strandRAB5CKCNH4: 42,156,891–42,181,146, reverse strandKCNH4HCRT: 42,184,060–42,185,452, reverse strandHCRTGHDC: 42,188,799–42,194,513, reverse strandGHDCSTAT5B: 42,199,176–42,288,633, reverse strandSTAT5BSTAT5A: 42,287,547–42,311,943, forward strandSTAT5ASTAT3: 42,313,322–42,388,574, reverse strandSTAT3CAVIN1: 42,402,449–42,423,322, reverse strandCAVIN1ATP6V0A1: 42,458,823–42,522,582, forward strandATP6V0A1NAGLU: 42,536,216–42,544,449, forward strandHSD17B1: 42,552,920–42,555,217, forward strandCOASY: 42,561,467–42,566,277, forward strandCOASYMLX: 42,567,067–42,573,239, forward strandMLXPSMC3IP: 42,572,310–42,577,729, reverse strandPSMC3IPRETREG3: 42,579,508–42,610,623, reverse strandRETREG3TUBG1: 42,609,411–42,615,253, forward strandTUBG2: 42,659,223–42,667,007, forward strandTUBG2PLEKHH3: 42,667,914–42,677,064, reverse strandPLEKHH3CCR10: 42,678,889–42,683,917, reverse strandCCR10CNTNAP1: 42,682,368–42,699,993, forward strandCNTNAP1EZH1: 42,700,270–42,745,069, reverse strandEZH1RAMP2: 42,758,447–42,763,537, forward strandRAMP2VPS25: 42,773,439–42,779,600, forward strandVPS25WNK4: 42,780,593–42,797,066, forward strandWNK4COA3: 42,793,154–42,798,719, reverse strandCOA3CNTD1: 42,798,800–42,811,587, forward strandBECN1: 42,809,108–42,833,350, reverse strandBECN1PSME3: 42,824,385–42,843,760, forward strandAOC2: 42,844,574–42,850,707, forward strandAOC2AOC3: 42,851,130–42,858,130, forward strandAOC3G6PC1: 42,900,722–42,923,502, forward strandG6PC1AARSD1: 42,950,424–42,964,498, reverse strandAARSD1PTGES3L-AARSD1: 42,950,526–42,980,528, reverse strandPTGES3L-AARSD1PTGES3L: 42,968,035–42,980,502, reverse strandPTGES3LRUNDC1: 42,980,552–42,995,142, forward strandRUNDC1RPL27: 42,998,265–43,002,973, forward strandVAT1: 42,999,182–43,025,123, reverse strandIFI35: 43,006,740–43,014,638, forward strandRND2: 43,025,210–43,047,509, forward strandBRCA1: 43,044,292–43,170,245, reverse strandBRCA1Diagram of PSMC3IP: 8 exons on the reverse strand of chromosome 17Exon 8: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 8: 42,572,310–42,573,024, 715 basesExon 7: 42,573,107–42,573,166, 60 basesExon 6: 42,573,311–42,573,364, 54 basesExon 5: 42,573,478–42,573,623, 146 basesExon 4: 42,574,099–42,574,210, 112 basesExon 3: 42,577,213–42,577,302, 90 basesExon 2: 42,577,461–42,577,561, 101 basesExon 1: 42,577,653–42,577,729, 77 bases876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.4 kb of the gene's 5.4 kb; 654 of those bases code for the protein.

How a genome test reads PSMC3IP

3

positions in PSMC3IP where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 5.4 kb of PSMC3IP, introns included, not only the 1.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PSMC3IP gene: PSMC3 interacting protein. Retrieved 17 October 2026, from https://dantelabs.com/genes/psmc3ip

Vancouver

Dante Labs. PSMC3IP gene: PSMC3 interacting protein [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/psmc3ip

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