Skip to content
Use your HSA or FSA funds

Gene

SLC34A3

solute carrier family 34 member 3

Summary

Cytogenetic location
9q34.3
Coordinates
Chromosome 9: 137,230,901–137,236,555 (GRCh38)
Exons
13 exons across 5.7 kb
Protein
599 amino acids
Also known as
NPTIIc, FLJ38680, NaPi-2c, NPT2C
MANE Select transcript
ENST00000673835.1NM_001177316.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Rickets (Hypophosphatemic and Vitamin D-Dependent)

    • Hereditary hypophosphatemic rickets (including X-linked hypophosphatemia)

      Inherited disorders of phosphate handling, most often caused by PHEX variants (X-linked hypophosphatemia) and less often by FGF23, DMP1, ENPP1 or SLC34A3, that lead to low blood phosphate and rickets.

      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Treatment with oral phosphate and active vitamin D, or with the anti-FGF23 antibody burosumab, can improve bone health and growth.

How SLC34A3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 9, with a bracket where SLC34A3 sits. SLC34A3 and 60 genes near it on chromosome 9, from 136,733,728 to 137,733,727.Chromosome 99q34.3p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.3136.8 Mb137 Mb137.2 Mb137.4 Mb137.6 Mb: 136,738,167–136,748,453, reverse strandLCN10: 136,738,167–136,743,356, reverse strandLCN6: 136,744,017–136,748,531, reverse strandLCN6LCN8: 136,754,386–136,758,543, reverse strandLCN8LCN15: 136,759,634–136,766,255, reverse strandLCN15TMEM141: 136,791,303–136,793,317, forward strand: 136,791,379–136,800,595, forward strandCCDC183: 136,796,338–136,807,741, forward strandRABL6: 136,807,848–136,841,187, forward strandAJM1: 136,842,478–136,848,801, forward strandAJM1PHPT1: 136,847,994–136,851,043, forward strandPHPT1MAMDC4: 136,850,943–136,860,802, forward strandMAMDC4EDF1: 136,862,113–136,866,343, reverse strandEDF1TRAF2: 136,881,903–136,929,221, forward strandTRAF2FBXW5: 136,938,431–136,950,122, reverse strandC8G: 136,942,532–136,946,980, forward strandC8GLCN12: 136,949,391–136,956,535, forward strandPTGDS: 136,975,053–136,981,750, forward strand: 136,977,518–136,985,435, forward strandLCNL1: 136,981,904–136,986,410, forward strandLCNL1PAXX: 136,992,400–136,994,074, forward strandPAXXCLIC3: 136,994,608–136,996,729, reverse strandCLIC3ABCA2: 137,007,226–137,028,915, reverse strandFUT7: 137,030,174–137,032,825, reverse strand: 137,031,241–137,040,436, reverse strandNPDC1: 137,037,577–137,046,700, reverse strandENTPD2: 137,048,107–137,054,069, reverse strandENTPD2SAPCD2: 137,062,127–137,070,593, reverse strandSAPCD2UAP1L1: 137,077,470–137,084,544, forward strandUAP1L1MAN1B1: 137,085,917–137,109,189, forward strandMAN1B1DPP7: 137,110,540–137,118,309, reverse strandDPP7GRIN1: 137,138,346–137,168,765, forward strandGRIN1LRRC26: 137,168,758–137,170,058, reverse strand: 137,168,854–137,171,984, reverse strandTMEM210: 137,170,858–137,172,056, reverse strandANAPC2: 137,174,784–137,189,028, reverse strandSSNA1: 137,188,640–137,190,371, forward strandTPRN: 137,191,617–137,204,193, reverse strandTMEM203: 137,204,082–137,205,648, reverse strandNDOR1: 137,205,662–137,219,371, forward strandRNF229: 137,217,494–137,219,361, forward strandRNF208: 137,219,577–137,222,312, reverse strandCYSRT1: 137,225,174–137,226,315, forward strandCYSRT1RNF224: 137,226,908–137,229,640, forward strandRNF224SLC34A3: 137,230,901–137,236,555, forward strandSLC34A3TUBB4B: 137,241,278–137,243,713, forward strandTUBB4BCIMIP2A: 137,243,584–137,247,770, reverse strandSTPG3: 137,250,608–137,253,483, forward strandNELFB: 137,255,210–137,273,542, forward strandTOR4A: 137,274,854–137,282,641, forward strandNRARP: 137,299,631–137,302,271, reverse strandNRARPEXD3: 137,306,894–137,423,911, reverse strandEXD3NOXA1: 137,422,752–137,434,451, forward strandNOXA1ENTPD8: 137,434,362–137,441,881, reverse strandENTPD8NSMF: 137,447,570–137,459,576, reverse strandNSMFPNPLA7: 137,459,952–137,550,560, reverse strandPNPLA7MRPL41: 137,550,424–137,552,555, forward strandMRPL41DPH7: 137,554,436–137,578,936, reverse strandDPH7ZMYND19: 137,582,066–137,590,520, reverse strandZMYND19ARRDC1: 137,605,619–137,617,859, forward strandARRDC1EHMT1: 137,618,901–137,870,016, forward strandEHMT1Diagram of SLC34A3: 13 exons on the forward strand of chromosome 9Exon 2: 2 known disease-causing sitesExon 3: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 5: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 7: 6 known disease-causing sitesExon 8: 1 known disease-causing siteExon 9: 3 known disease-causing sitesExon 10: 3 known disease-causing sitesExon 11: 4 known disease-causing sitesExon 12: 9 known disease-causing sitesExon 13: 13 known disease-causing sitesExon 1: 137,230,901–137,230,938, 38 basesExon 2: 137,231,664–137,231,787, 124 basesExon 3: 137,232,072–137,232,161, 90 basesExon 4: 137,232,575–137,232,703, 129 basesExon 5: 137,232,784–137,232,927, 144 basesExon 6: 137,233,004–137,233,115, 112 basesExon 7: 137,233,209–137,233,404, 196 basesExon 8: 137,233,633–137,233,722, 90 basesExon 9: 137,233,863–137,233,941, 79 basesExon 10: 137,234,109–137,234,276, 168 basesExon 11: 137,234,416–137,234,532, 117 basesExon 12: 137,234,607–137,234,731, 125 basesExon 13: 137,235,952–137,236,555, 604 bases123456789101112135′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2 kb of the gene's 5.7 kb; 1,800 of those bases code for the protein.

How a genome test reads SLC34A3

63

positions in SLC34A3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 5.7 kb of SLC34A3, introns included, not only the 2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SLC34A3 gene: solute carrier family 34 member 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/slc34a3

Vancouver

Dante Labs. SLC34A3 gene: solute carrier family 34 member 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/slc34a3

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test