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Gene

PAPPA2

pappalysin 2

Summary

Cytogenetic location
1q25.2
Coordinates
Chromosome 1: 176,463,175–176,845,601 (GRCh38)
Exons
23 exons across 382.4 kb
Protein
1,791 amino acids
Also known as
PAPPE, PAPP-A2
Previous symbols
PLAC3
MANE Select transcript
ENST00000367662.5NM_020318.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PAPPA2 yet. The test sequences your whole genome, so your data includes it all the same.

How PAPPA2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where PAPPA2 sits. PAPPA2 and 3 genes near it on chromosome 1, from 176,080,748 to 177,228,028.Chromosome 11q25.2p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44176.2 Mb176.4 Mb176.6 Mb176.8 Mb177 Mb177.2 MbCOP1: 175,943,861–176,207,523, reverse strandCOP1PAPPA2: 176,463,175–176,845,601, forward strandPAPPA2ASTN1: 176,857,302–177,164,973, reverse strandASTN1BRINP2: 177,170,890–177,282,422, forward strandBRINP2Diagram of PAPPA2: 23 exons on the forward strand of chromosome 1Exon 8: 2 known disease-causing sitesExon 11: 1 known disease-causing siteExon 1: 176,463,175–176,463,418, 244 basesExon 2: 176,555,407–176,557,241, 1,835 basesExon 3: 176,594,524–176,595,595, 1,072 basesExon 4: 176,670,970–176,671,115, 146 basesExon 5: 176,690,137–176,690,430, 294 basesExon 6: 176,692,126–176,692,318, 193 basesExon 7: 176,695,738–176,695,859, 122 basesExon 8: 176,699,100–176,699,589, 490 basesExon 9: 176,702,607–176,702,735, 129 basesExon 10: 176,706,359–176,706,450, 92 basesExon 11: 176,709,983–176,710,176, 194 basesExon 12: 176,711,835–176,711,981, 147 basesExon 13: 176,739,626–176,739,761, 136 basesExon 14: 176,739,980–176,740,196, 217 basesExon 15: 176,765,666–176,765,837, 172 basesExon 16: 176,769,607–176,769,784, 178 basesExon 17: 176,770,967–176,771,180, 214 basesExon 18: 176,789,809–176,789,977, 169 basesExon 19: 176,791,347–176,791,482, 136 basesExon 20: 176,793,560–176,793,669, 110 basesExon 21: 176,800,061–176,800,132, 72 basesExon 22: 176,840,173–176,840,271, 99 basesExon 23: 176,842,380–176,845,601, 3,222 bases15101520235′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 9.7 kb of the gene's 382.4 kb; 5,376 of those bases code for the protein.

How a genome test reads PAPPA2

3

positions in PAPPA2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 382.4 kb of PAPPA2, introns included, not only the 9.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PAPPA2 gene: pappalysin 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/pappa2

Vancouver

Dante Labs. PAPPA2 gene: pappalysin 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/pappa2

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