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Gene

ZNF687

zinc finger protein 687

Summary

Cytogenetic location
1q21.3
Coordinates
Chromosome 1: 151,282,299–151,292,176 (GRCh38)
Exons
9 exons across 9.9 kb
Protein
1,237 amino acids
Inheritance
Autosomal dominant
Also known as
KIAA1441
MANE Select transcript
ENST00000336715.11NM_020832.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Familial Paget Disease of Bone

    • Paget disease of bone 6 (ZNF687-related)Autosomal dominant

      A form of Paget disease of bone caused by ZNF687 variants, which can be severe and has been linked to giant cell tumours of bone.

      • 1 GenCC submitter rates it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How ZNF687 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 1, with a bracket where ZNF687 sits. ZNF687 and 34 genes near it on chromosome 1, from 150,787,238 to 151,787,237.Chromosome 11q21.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44150.8 Mb151 Mb151.2 Mb151.4 Mb151.6 MbCTSK: 150,794,880–150,809,577, reverse strandCTSKARNT: 150,808,617–150,876,771, reverse strandARNTCTXND2: 150,887,136–150,913,292, forward strandCTXND2SETDB1: 150,926,263–150,964,748, forward strandSETDB1CERS2: 150,959,099–150,977,396, reverse strandCERS2ANXA9: 150,981,321–150,996,077, forward strandANXA9MINDY1: 150,995,125–151,008,376, reverse strandPRUNE1: 151,008,408–151,035,714, forward strandBNIPL: 151,036,321–151,047,720, forward strandC1orf56: 151,047,746–151,051,986, forward strandC1orf56CDC42SE1: 151,050,242–151,070,325, reverse strandCDC42SE1MLLT11: 151,054,177–151,069,544, forward strandMLLT11GABPB2: 151,070,514–151,130,109, forward strandGABPB2SEMA6C: 151,131,685–151,147,813, reverse strandTIPE2: 151,156,621–151,160,255, forward strandSCNM1: 151,156,664–151,179,006, forward strandSCNM1LYSMD1: 151,159,748–151,165,948, reverse strandTMOD4: 151,169,984–151,176,284, reverse strandTMOD4VPS72: 151,176,304–151,195,321, reverse strandVPS72PIP5K1A: 151,197,949–151,249,538, forward strandPIP5K1APSMD4: 151,254,709–151,279,502, forward strandPSMD4ZNF687: 151,282,299–151,292,176, forward strandZNF687PI4KB: 151,291,792–151,328,394, reverse strandPI4KBRFX5: 151,340,640–151,347,339, reverse strandRFX5SELENBP1: 151,364,157–151,372,716, reverse strandSELENBP1PSMB4: 151,399,556–151,401,941, forward strandPSMB4POGZ: 151,402,724–151,459,511, reverse strandPOGZCGN: 151,510,139–151,538,692, forward strandCGNTUFT1: 151,540,305–151,583,583, forward strandTUFT1SNX27: 151,611,985–151,699,091, forward strandSNX27CELF3: 151,700,058–151,716,803, reverse strandCELF3RIIAD1: 151,710,433–151,729,805, forward strandRIIAD1MRPL9: 151,759,643–151,763,522, reverse strandMRPL9OAZ3: 151,762,899–151,771,334, forward strandOAZ3TDRKH: 151,769,799–151,791,416, reverse strandTDRKHDiagram of ZNF687: 9 exons on the forward strand of chromosome 1Exon 1: 151,282,299–151,282,395, 97 basesExon 2: 151,286,275–151,288,406, 2,132 basesExon 3: 151,288,528–151,288,706, 179 basesExon 4: 151,289,095–151,289,271, 177 basesExon 5: 151,289,378–151,289,540, 163 basesExon 6: 151,289,678–151,290,007, 330 basesExon 7: 151,290,122–151,290,234, 113 basesExon 8: 151,290,432–151,290,573, 142 basesExon 9: 151,290,715–151,292,176, 1,462 bases1234567895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.8 kb of the gene's 9.9 kb; 3,714 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ZNF687 gene: zinc finger protein 687. Retrieved 17 October 2026, from https://dantelabs.com/genes/znf687

Vancouver

Dante Labs. ZNF687 gene: zinc finger protein 687 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/znf687

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