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Gene

CORO1A

coronin 1A

Summary

Cytogenetic location
16p11.2
Coordinates
Chromosome 16: 30,183,602–30,189,076 (GRCh38)
Exons
11 exons across 5.5 kb
Protein
461 amino acids
Inheritance
Autosomal recessive
Also known as
HCORO1, p57, coronin-1
MANE Select transcript
ENST00000219150.10NM_007074.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Severe Combined Immunodeficiency

    • Autosomal recessive

      Severe combined immunodeficiency (SCID) comprises a group of rare monogenic primary immunodeficiency disorders characterized by a lack of functional peripheral T lymphocytes resulting in early-onset severe respiratory infections and failure to thrive. They are classified according to immunological phenotype into SCID with absence of T cells but presence of B cells (T-B+ SCID) or SCID with absence of both (T-B- SCID). Both of these groups include several forms, with or without natural killer (NK) cells.

      • ClinGen rates the link definitive
      • 2 GenCC submitters rate it definitive or strong

Broader groupings

  • Other Inborn Errors of Immunity

    • Immunodeficiency Disease

      One of 170 genes linked to it

      Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

      • ClinGen rates the link definitive
      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How CORO1A is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 16, with a bracket where CORO1A sits. CORO1A and 51 genes near it on chromosome 16, from 29,686,339 to 30,686,338.Chromosome 1616p11.2p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.329.8 Mb30 Mb30.2 Mb30.4 Mb30.6 MbQPRT: 29,662,957–29,698,704, forward strandQPRTC16orf54: 29,742,463–29,746,079, reverse strandC16orf54ZG16: 29,760,591–29,783,885, forward strandZG16KIF22: 29,790,137–29,805,388, forward strandMAZ: 29,805,637–29,811,176, forward strandPRRT2: 29,811,382–29,815,892, forward strand: 29,812,261–29,820,092, forward strandPAGR1: 29,816,086–29,822,489, forward strandPAGR1: 29,817,239–29,830,627, forward strandMVP: 29,820,394–29,848,039, forward strandMVPCDIPT: 29,857,474–29,863,414, reverse strandCDIPTSEZ6L2: 29,871,159–29,899,582, reverse strandSEZ6L2ASPHD1: 29,900,363–29,919,864, forward strandASPHD1KCTD13: 29,903,877–29,926,236, reverse strandKCTD13TMEM219: 29,940,885–29,973,052, forward strandTMEM219TAOK2: 29,973,675–29,992,262, forward strandHIRIP3: 29,992,314–29,996,126, reverse strandINO80E: 29,994,983–30,005,794, forward strandINO80EDOC2A: 30,005,507–30,023,270, reverse strandDOC2AFIMP1: 30,023,198–30,027,736, forward strandFIMP1TLCD3B: 30,024,425–30,052,978, reverse strand: 30,053,101–30,071,526, forward strandALDOA: 30,064,164–30,070,457, forward strandPPP4C: 30,075,967–30,085,391, forward strandTBX6: 30,085,793–30,091,933, reverse strandTBX6YPEL3: 30,092,314–30,096,915, reverse strandYPEL3GDPD3: 30,104,810–30,114,034, reverse strandGDPD3MAPK3: 30,114,104–30,123,506, reverse strandMAPK3CORO1A: 30,183,602–30,189,076, forward strandCORO1ABOLA2B: 30,192,928–30,194,306, reverse strandBOLA2BSLX1A: 30,193,875–30,197,566, forward strandSLX1ASULT1A3: 30,198,059–30,204,324, forward strandSULT1A3NPIPB13: 30,222,893–30,255,268, reverse strandCD2BP2: 30,341,365–30,355,851, reverse strandCD2BP2TBC1D10B: 30,357,102–30,370,529, reverse strandTBC1D10BMYL11: 30,370,332–30,377,991, forward strandMYL11ZNF48: 30,378,106–30,400,108, forward strandSEPTIN1: 30,378,135–30,395,991, reverse strandSEPTIN1ZNF771: 30,407,143–30,431,108, forward strandDCTPP1: 30,413,033–30,430,162, reverse strandSEPHS2: 30,443,631–30,445,874, reverse strandSEPHS2ITGAL: 30,472,658–30,523,567, forward strandITGALZNF768: 30,524,001–30,527,328, reverse strandZNF768: 30,525,923–30,534,852, reverse strandZNF747: 30,529,534–30,535,347, reverse strandZNF747ZNF764: 30,553,764–30,558,524, reverse strandZNF688: 30,569,281–30,572,734, reverse strandZNF688ZNF785: 30,573,740–30,585,806, reverse strandZNF689: 30,602,558–30,624,012, reverse strandZNF689: 30,610,211–30,610,351, reverse strandPRR14: 30,650,696–30,656,427, forward strandPRR14FBRS: 30,658,431–30,670,810, forward strandFBRSDiagram of CORO1A: 11 exons on the forward strand of chromosome 16Exon 2: 2 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 4: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 6: 3 known disease-causing sitesExon 7: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 10: 2 known disease-causing sitesExon 1: 30,183,602–30,183,725, 124 basesExon 2: 30,185,209–30,185,407, 199 basesExon 3: 30,186,598–30,186,720, 123 basesExon 4: 30,186,816–30,186,945, 130 basesExon 5: 30,187,039–30,187,223, 185 basesExon 6: 30,187,382–30,187,501, 120 basesExon 7: 30,187,725–30,187,829, 105 basesExon 8: 30,187,942–30,188,087, 146 basesExon 9: 30,188,192–30,188,249, 58 basesExon 10: 30,188,361–30,188,576, 216 basesExon 11: 30,188,860–30,189,076, 217 bases12345678910115′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.6 kb of the gene's 5.5 kb; 1,386 of those bases code for the protein.

How a genome test reads CORO1A

15

positions in CORO1A where ClinVar classes a change as pathogenic or likely pathogenic

1 of them (6.7%) falls in a region short reads find hard.

  • Low mappability (1 site)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (1 site)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 5.5 kb of CORO1A, introns included, not only the 1.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CORO1A gene: coronin 1A. Retrieved 16 October 2026, from https://dantelabs.com/genes/coro1a

Vancouver

Dante Labs. CORO1A gene: coronin 1A [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/coro1a

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