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Gene

IL21R

interleukin 21 receptor

Summary

Cytogenetic location
16p12.1
Coordinates
Chromosome 16: 27,402,174–27,452,042 (GRCh38)
Exons
9 exons across 49.9 kb
Protein
538 amino acids
Also known as
CD360
MANE Select transcript
ENST00000337929.8NM_181078.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Other Inborn Errors of Immunity

      • Immunodeficiency Disease

        One of 170 genes linked to it

        Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

        • ClinGen rates the link definitive
        • 3 GenCC submitters rate it definitive or strong
        What knowing changes

        HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

    How IL21R is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 16, with a bracket where IL21R sits. IL21R and 7 genes near it on chromosome 16, from 26,927,108 to 27,927,107.Chromosome 1616p12.1p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.327 Mb27.2 Mb27.4 Mb27.6 Mb27.8 MbC16orf82: 27,066,927–27,069,166, forward strandC16orf82KDM8: 27,203,476–27,225,987, forward strandKDM8NSMCE1: 27,222,306–27,268,788, reverse strandNSMCE1IL4R: 27,313,462–27,365,558, forward strandIL4RIL21R: 27,402,174–27,452,042, forward strandIL21RGTF3C1: 27,459,555–27,549,960, reverse strandGTF3C1KATNIP: 27,550,133–27,780,371, forward strandKATNIPGSG1L: 27,787,526–28,063,754, reverse strandGSG1LDiagram of IL21R: 9 exons on the forward strand of chromosome 16Exon 2: 1 known disease-causing siteExon 5: 2 known disease-causing sitesExon 6: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 1: 27,402,174–27,402,618, 445 basesExon 2: 27,430,056–27,430,120, 65 basesExon 3: 27,434,347–27,434,449, 103 basesExon 4: 27,437,488–27,437,687, 200 basesExon 5: 27,442,962–27,443,116, 155 basesExon 6: 27,444,542–27,444,719, 178 basesExon 7: 27,445,177–27,445,276, 100 basesExon 8: 27,446,007–27,446,088, 82 basesExon 9: 27,448,534–27,452,042, 3,509 bases1246895′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 4.8 kb of the gene's 49.9 kb; 1,617 of those bases code for the protein.

    How a genome test reads IL21R

    9

    positions in IL21R where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 49.9 kb of IL21R, introns included, not only the 4.8 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). IL21R gene: interleukin 21 receptor. Retrieved 17 October 2026, from https://dantelabs.com/genes/il21r

    Vancouver

    Dante Labs. IL21R gene: interleukin 21 receptor [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/il21r

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