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Gene

TLR3

toll like receptor 3

Summary

Cytogenetic location
4q35.1
Coordinates
Chromosome 4: 186,069,156–186,088,073 (GRCh38)
Exons
5 exons across 18.9 kb
Protein
904 amino acids
Also known as
CD283
MANE Select transcript
ENST00000296795.8NM_003265.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TLR3 yet. The test sequences your whole genome, so your data includes it all the same.

How TLR3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 4, with a bracket where TLR3 sits. TLR3 and 8 genes near it on chromosome 4, from 185,578,615 to 186,578,614.Chromosome 44q35.1p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.2185.6 Mb185.8 Mb186 Mb186.2 Mb186.4 MbSORBS2: 185,585,444–185,956,721, reverse strandSORBS2TLR3: 186,069,156–186,088,073, forward strandTLR3FAM149A: 186,104,419–186,175,437, forward strandFAM149ACYP4V2: 186,191,258–186,215,245, forward strandCYP4V2: 186,208,979–186,258,469, forward strandKLKB1: 186,225,424–186,258,476, forward strandKLKB1F11: 186,260,159–186,291,745, forward strandF11: 186,426,546–186,555,328, reverse strandMTNR1A: 186,526,792–186,555,567, reverse strandMTNR1ADiagram of TLR3: 5 exons on the forward strand of chromosome 4Exon 5: 1 known disease-causing siteExon 1: 186,069,156–186,069,248, 93 basesExon 2: 186,076,613–186,077,060, 448 basesExon 3: 186,078,840–186,079,031, 192 basesExon 4: 186,082,320–186,084,172, 1,853 basesExon 5: 186,084,645–186,088,073, 3,429 bases123455′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6 kb of the gene's 18.9 kb; 2,715 of those bases code for the protein.

How a genome test reads TLR3

1

position in TLR3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 18.9 kb of TLR3, introns included, not only the 6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TLR3 gene: toll like receptor 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/tlr3

Vancouver

Dante Labs. TLR3 gene: toll like receptor 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tlr3

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