Traits

Traits linked to ZNF408

zinc finger protein 408

The Human Phenotype Ontology links 72 traits to ZNF408, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the eye

Trait	Cât de frecvent apare
Decreased clarity of vision	Întotdeauna
Difficulties with night vision	Întotdeauna
Exudative vitreoretinopathy	Întotdeauna
Limited peripheral vision	Întotdeauna
Optic disc pallor	Întotdeauna
Posterior subcapsular cataract	Întotdeauna
Rod-cone dystrophy	Întotdeauna
Spicular pigmentation of the retina	Întotdeauna
Vitreoretinopathy	Întotdeauna
Abnormal electroretinogram	Foarte des (80–99%)
Abnormal retinal pigmentation	Foarte des (80–99%)
Blindness	Foarte des (80–99%)
Extreme sensitivity of the eyes to light	Foarte des (80–99%)
Involuntary, rapid, rhythmic eye movements	Foarte des (80–99%)
Optic atrophy	Foarte des (80–99%)
Progressive night blindness	Foarte des (80–99%)
Retina degeneration	Foarte des (80–99%)
Visual impairment	Foarte des (80–99%)
Abnormal central response of multifocal electroretinogram	Des (30–79%)
Abnormal full-field electroretinogram	Des (30–79%)
Abnormal optic disc morphology	Des (30–79%)
Bulging cornea	Des (30–79%)
Chorioretinal atrophy	Des (30–79%)
Close sighted	Des (30–79%)
Cystoid macular edema	Des (30–79%)
Esodeviation	Des (30–79%)
Eye muscle paralysis	Des (30–79%)
Falciform retinal fold	Des (30–79%)
Glaucoma	Des (30–79%)
Horizontal nystagmus	Des (30–79%)
Loss of peripheral vision	Des (30–79%)
Optic disc drusen	Des (30–79%)
Peripapillary atrophy	Des (30–79%)
Photoreceptor outer segment loss on macular OCT	Des (30–79%)
Retinal atrophy	Des (30–79%)
Retinal detachment	Des (30–79%)
Severe near sightedness	Des (30–79%)
Subretinal fluid	Des (30–79%)
Tractional retinal detachment	Des (30–79%)
Abnormal color vision	Uneori (5–29%)
Abnormally small eyeball	Uneori (5–29%)
Clouding of the lens of the eye	Uneori (5–29%)
Cortical cataract	Uneori (5–29%)
Epiretinal membrane	Uneori (5–29%)
Eye floaters	Uneori (5–29%)
Macular edema	Uneori (5–29%)
Marked vision impairment	Uneori (5–29%)
Patchy atrophy of the retinal pigment epithelium	Uneori (5–29%)
Photopsia	Uneori (5–29%)
Posterior vitreous detachment	Uneori (5–29%)
Retinal exudate	Uneori (5–29%)
Retinal hole	Uneori (5–29%)
Rhegmatogenous retinal detachment	Uneori (5–29%)
Yellowish cloudy center of lens	Uneori (5–29%)
Progressive loss of vision	Neînregistrat

Abnormality of the cardiovascular system

Trait	Cât de frecvent apare
Narrowing of blood vessels in back of eye	Întotdeauna
Abnormality of retina blood vessels	Foarte des (80–99%)
Avascular peripheral retina	Foarte des (80–99%)
Retinal neovascularization	Des (30–79%)
Macular exudate	Uneori (5–29%)
Macular telangiectasia	Uneori (5–29%)

Abnormality of the ear

Trait	Cât de frecvent apare
Conductive deafness	Foarte des (80–99%)
Sensorineural hearing impairment	Foarte des (80–99%)
Hearing impairment	Uneori (5–29%)

Abnormality of the nervous system

Trait	Cât de frecvent apare
Intellectual disability, mild	Uneori (5–29%)
Mild global developmental delay	Uneori (5–29%)
Motor delay	Uneori (5–29%)

Laboratory abnormality

Trait	Cât de frecvent apare
Hyperinsulinemia	Des (30–79%)
Swelling caused by excess lymph fluid under skin	Uneori (5–29%)

Abnormality of blood and blood-forming tissues

Trait	Cât de frecvent apare
Vitreous hemorrhage	Uneori (5–29%)

Abnormality of head or neck

Trait	Cât de frecvent apare
Abnormally small head	Uneori (5–29%)

Abnormality of the musculoskeletal system

Trait	Cât de frecvent apare
Low solidness and mass of the bones	Uneori (5–29%)

Cât de frecvent apare în rândul persoanelor cu una dintre afecțiunile asociate genei, cel mai des întâlnit dintre acestea, conform Human Phenotype Ontology. Aceste pagini descriu trăsături și cercetările din spatele lor; ele nu reprezintă un diagnostic, iar pentru simptome trebuie să vă adresați medicului sau consilierului genetic.

De unde provin aceste informații

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ZNF408 and how often each is seen. Find out more at hpo.jax.org.

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