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Gene

PCK2

phosphoenolpyruvate carboxykinase 2, mitochondrial

Summary

Cytogenetic location
14q11.2-q12
Coordinates
Chromosome 14: 24,094,311–24,104,125 (GRCh38)
Exons
10 exons across 9.8 kb
Protein
640 amino acids
Also known as
PEPCK, PEPCK2
MANE Select transcript
ENST00000216780.9NM_004563.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PCK2 yet. The test sequences your whole genome, so your data includes it all the same.

How PCK2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 14, with a bracket where PCK2 sits. PCK2 and 43 genes near it on chromosome 14, from 23,599,218 to 24,599,217.Chromosome 1414q11.2-q12p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.3323.6 Mb23.8 Mb24 Mb24.2 Mb24.4 MbDHRS2: 23,630,115–23,645,639, forward strandDHRS2DHRS4: 23,953,713–23,969,279, forward strandDHRS4DHRS4L2: 23,969,874–24,006,408, forward strandDHRS4L2CARMIL3: 24,051,387–24,069,734, forward strandCPNE6: 24,070,837–24,078,100, forward strandCPNE6NRL: 24,078,662–24,115,026, reverse strandNRLPCK2: 24,094,311–24,104,125, forward strandPCK2DCAF11: 24,114,010–24,125,615, forward strandDCAF11: 24,120,956–24,131,829, forward strandFITM1: 24,130,659–24,132,849, forward strandPSME1: 24,136,142–24,138,967, forward strandEMC9: 24,138,958–24,142,023, reverse strandPSME2: 24,143,360–24,147,570, reverse strandRNF31: 24,146,683–24,160,660, forward strand: 24,147,548–24,166,452, forward strandIRF9: 24,161,101–24,168,043, forward strandREC8: 24,171,853–24,180,923, forward strandREC8IPO4: 24,180,043–24,188,990, reverse strand: 24,180,395–24,190,416, reverse strandTM9SF1: 24,189,140–24,196,287, reverse strand: 24,189,157–24,213,473, reverse strandTSSK4: 24,205,696–24,208,362, forward strandCHMP4A: 24,209,581–24,213,830, reverse strandMDP1: 24,213,939–24,216,070, reverse strandNEDD8-MDP1: 24,213,955–24,232,352, reverse strandNEDD8: 24,216,802–24,232,539, reverse strandNEDD8GMPR2: 24,232,211–24,239,246, forward strandTINF2: 24,234,009–24,242,666, reverse strandTGM1: 24,249,114–24,264,432, reverse strandTGM1RABGGTA: 24,265,468–24,271,620, reverse strandDHRS1: 24,290,594–24,300,136, reverse strandDHRS1NOP9: 24,299,825–24,309,124, forward strandNOP9CIDEB: 24,305,187–24,311,454, reverse strandCIDEBLTB4R2: 24,305,734–24,312,053, forward strandLTB4R: 24,311,188–24,318,036, forward strandADCY4: 24,318,091–24,335,208, reverse strandRIPK3: 24,336,025–24,340,022, reverse strandNFATC4: 24,365,673–24,379,613, forward strandNFATC4NYNRIN: 24,398,861–24,419,304, forward strandNYNRINKHNYN: 24,423,052–24,441,846, forward strandKHNYNCBLN3: 24,423,886–24,430,972, reverse strandCBLN3SDR39U1: 24,439,651–24,442,905, reverse strandSDR39U1CMA1: 24,505,353–24,508,271, reverse strandCMA1CTSG: 24,573,518–24,576,250, reverse strandCTSGDiagram of PCK2: 10 exons on the forward strand of chromosome 14Exon 4: 2 known disease-causing sitesExon 1: 24,094,311–24,094,434, 124 basesExon 2: 24,096,892–24,097,137, 246 basesExon 3: 24,098,203–24,098,387, 185 basesExon 4: 24,098,475–24,098,678, 204 basesExon 5: 24,099,049–24,099,236, 188 basesExon 6: 24,099,558–24,099,720, 163 basesExon 7: 24,099,995–24,100,213, 219 basesExon 8: 24,102,753–24,102,890, 138 basesExon 9: 24,103,160–24,103,255, 96 basesExon 10: 24,103,510–24,104,125, 616 bases123456789105′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.2 kb of the gene's 9.8 kb; 1,923 of those bases code for the protein.

How a genome test reads PCK2

3

positions in PCK2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 9.8 kb of PCK2, introns included, not only the 2.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PCK2 gene: phosphoenolpyruvate carboxykinase 2, mitochondrial. Retrieved 17 October 2026, from https://dantelabs.com/genes/pck2

Vancouver

Dante Labs. PCK2 gene: phosphoenolpyruvate carboxykinase 2, mitochondrial [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/pck2

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