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Gene

NRL

neural retina leucine zipper

Summary

Cytogenetic location
14q11.2-q12
Coordinates
Chromosome 14: 24,078,662–24,114,949 (GRCh38)
Exons
3 exons across 36.3 kb
Protein
237 amino acids
Also known as
D14S46E, RP27, NRL-MAF
MANE Select transcript
ENST00000561028.6NM_001354768.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Vitreoretinopathy

    • Vitreoretinal Degeneration
      • 1 GenCC submitter rates it definitive or strong

Broader groupings

  • Retinitis Pigmentosa

    • One of 77 genes linked to it

      A group of inherited retinal dystrophies with progressive loss of rod and then cone photoreceptors, causing night blindness and gradual loss of peripheral vision.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong

How NRL is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 14, with a bracket where NRL sits. NRL and 43 genes near it on chromosome 14, from 23,596,806 to 24,596,805.Chromosome 1414q11.2-q12p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.3323.6 Mb23.8 Mb24 Mb24.2 Mb24.4 MbDHRS2: 23,630,115–23,645,639, forward strandDHRS2DHRS4: 23,953,713–23,969,279, forward strandDHRS4DHRS4L2: 23,969,874–24,006,408, forward strandDHRS4L2CARMIL3: 24,051,387–24,069,734, forward strandCPNE6: 24,070,837–24,078,100, forward strandCPNE6NRL: 24,078,662–24,114,949, reverse strandNRLPCK2: 24,094,053–24,110,598, forward strandPCK2DCAF11: 24,114,010–24,125,615, forward strandDCAF11: 24,120,956–24,131,829, forward strandFITM1: 24,130,659–24,132,849, forward strandPSME1: 24,136,142–24,138,967, forward strandEMC9: 24,138,958–24,142,023, reverse strandPSME2: 24,143,360–24,147,570, reverse strandRNF31: 24,146,683–24,160,660, forward strand: 24,147,548–24,166,452, forward strandIRF9: 24,161,101–24,168,043, forward strandREC8: 24,171,853–24,180,923, forward strandREC8IPO4: 24,180,043–24,188,990, reverse strand: 24,180,395–24,190,416, reverse strandTM9SF1: 24,189,140–24,196,287, reverse strand: 24,189,157–24,213,473, reverse strandTSSK4: 24,205,696–24,208,362, forward strandCHMP4A: 24,209,581–24,213,830, reverse strandMDP1: 24,213,939–24,216,070, reverse strandNEDD8-MDP1: 24,213,955–24,232,352, reverse strandNEDD8: 24,216,802–24,232,539, reverse strandNEDD8GMPR2: 24,232,211–24,239,246, forward strandTINF2: 24,234,009–24,242,666, reverse strandTGM1: 24,249,114–24,264,432, reverse strandTGM1RABGGTA: 24,265,468–24,271,620, reverse strandDHRS1: 24,290,594–24,300,136, reverse strandDHRS1NOP9: 24,299,825–24,309,124, forward strandNOP9CIDEB: 24,305,187–24,311,454, reverse strandCIDEBLTB4R2: 24,305,734–24,312,053, forward strandLTB4R2LTB4R: 24,311,188–24,318,036, forward strandADCY4: 24,318,091–24,335,208, reverse strandRIPK3: 24,336,025–24,340,022, reverse strandNFATC4: 24,365,673–24,379,613, forward strandNFATC4NYNRIN: 24,398,861–24,419,304, forward strandNYNRINKHNYN: 24,423,052–24,441,846, forward strandKHNYNCBLN3: 24,423,886–24,430,972, reverse strandCBLN3SDR39U1: 24,439,651–24,442,905, reverse strandSDR39U1CMA1: 24,505,353–24,508,271, reverse strandCMA1CTSG: 24,573,518–24,576,250, reverse strandCTSGDiagram of NRL: 3 exons on the reverse strand of chromosome 14Exon 3: 3 known disease-causing sitesExon 2: 11 known disease-causing sitesExon 3: 24,078,662–24,081,568, 2,907 basesExon 2: 24,082,468–24,082,875, 408 basesExon 1: 24,114,722–24,114,949, 228 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.5 kb of the gene's 36.3 kb; 714 of those bases code for the protein.

How a genome test reads NRL

15

positions in NRL where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 36.3 kb of NRL, introns included, not only the 3.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NRL gene: neural retina leucine zipper. Retrieved 16 October 2026, from https://dantelabs.com/genes/nrl

Vancouver

Dante Labs. NRL gene: neural retina leucine zipper [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/nrl

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