Trait
Heat intolerance
The inability to maintain a comfortable body temperature in warm or hot weather.
Summary
- Also called
- Intolerance to heat and fevers
- Body system
- Laboratory abnormality
Reference genomeGRCh38hg38
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Get my Genome Test36 genes linked to Heat intolerance
Changes in these genes cause rare conditions in which Heat intolerance is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| EDARectodysplasin A receptor | Always | In 2 conditions |
| EDARADDEDAR associated via death domain | Always | In 2 conditions |
| ITPR2inositol 1,4,5-trisphosphate receptor type 2 | Always | In 1 condition |
| LBX1ladybird homeobox 1 | Always | In 1 condition |
| MAP2K1mitogen-activated protein kinase kinase 1 | Always | In 1 condition |
| MAP2K2mitogen-activated protein kinase kinase 2 | Always | In 1 condition |
| PI4K2Aphosphatidylinositol 4-kinase type 2 alpha | Always | In 1 condition |
| RNU2-2RNA, U2 small nuclear 2 | Always | In 1 condition |
| ZMYM3zinc finger MYM-type containing 3 | Always | In 1 condition |
| ABCA12ATP binding cassette subfamily A member 12 | Very often (80–99%) | In 1 condition |
| ALOX12Barachidonate 12-lipoxygenase, 12R type | Very often (80–99%) | In 1 condition |
| ALOXE3arachidonate epidermal lipoxygenase 3 | Very often (80–99%) | In 2 conditions |
| ASPRV1aspartic peptidase retroviral like 1 | Very often (80–99%) | In 1 condition |
| CYP4F22cytochrome P450 family 4 subfamily F member 22 | Very often (80–99%) | In 1 condition |
| LIPNlipase family member N | Very often (80–99%) | In 1 condition |
| NIPAL4NIPA like domain containing 4 | Very often (80–99%) | In 1 condition |
| SDR9C7short chain dehydrogenase/reductase family 9C member 7 | Very often (80–99%) | In 1 condition |
| SULT2B1sulfotransferase family 2B member 1 | Very often (80–99%) | In 1 condition |
| TGM1transglutaminase 1 | Very often (80–99%) | In 1 condition |
| GLAgalactosidase alpha | Often (30–79%) | In 1 condition |
| KRT14keratin 14 | Often (30–79%) | In 3 conditions |
| KRT5keratin 5 | Often (30–79%) | In 2 conditions |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Often (30–79%) | In 1 condition |
| SHANK3SH3 and multiple ankyrin repeat domains 3 | Often (30–79%) | In 1 condition |
| HNRNPKheterogeneous nuclear ribonucleoprotein K | Sometimes (5–29%) | In 2 conditions |
| LDHAlactate dehydrogenase A | Sometimes (5–29%) | In 1 condition |
| NECTIN4nectin cell adhesion molecule 4 | Sometimes (5–29%) | In 1 condition |
| OCA2OCA2 melanosomal transmembrane protein | Sometimes (5–29%) | In 1 condition |
| POFUT1protein O-fucosyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| POGLUT1protein O-glucosyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| PSENENpresenilin enhancer, gamma-secretase subunit | Sometimes (5–29%) | In 1 condition |
| UBE3Aubiquitin protein ligase E3A | Sometimes (5–29%) | In 3 conditions |
| CLDN10claudin 10 | Not recorded | In 1 condition |
| EDAectodysplasin A | Not recorded | In 1 condition |
| NFKBIANFKB inhibitor alpha | Not recorded | In 1 condition |
| ORAI1ORAI calcium release-activated calcium modulator 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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