Trait

Widened subarachnoid space

An increase in size of the anatomic space between the arachnoid membrane and pia mater.

Also called: Enlarged subarachnoid space
Body system: Abnormality of the nervous system

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28 genes linked to Widened subarachnoid space

Changes in these genes cause rare conditions in which Widened subarachnoid space is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
ATP11AATPase phospholipid transporting 11A	Always	In 1 condition
DTYMKdeoxythymidylate kinase	Always	In 1 condition
GTPBP2GTP binding protein 2	Always	In 1 condition
HOXA13homeobox A13	Always	In 1 condition
PIGAphosphatidylinositol glycan anchor biosynthesis class A	Always	In 1 condition
PIGWphosphatidylinositol glycan anchor biosynthesis class W	Always	In 1 condition
SLC33A1solute carrier family 33 member 1	Always	In 1 condition
COX16cytochrome c oxidase assembly factor COX16	Often (30–79%)	In 1 condition
DNM1dynamin 1	Often (30–79%)	In 1 condition
GCDHglutaryl-CoA dehydrogenase	Often (30–79%)	In 1 condition
OTUD7AOTU deubiquitinase 7A	Often (30–79%)	In 1 condition
AHCYadenosylhomocysteinase	Sometimes (5–29%)	In 1 condition
ALDH7A1aldehyde dehydrogenase 7 family member A1	Sometimes (5–29%)	In 1 condition
ALG11ALG11 alpha-1,2-mannosyltransferase	Sometimes (5–29%)	In 1 condition
ALG2ALG2 alpha-1,3/1,6-mannosyltransferase	Sometimes (5–29%)	In 1 condition
ALG9ALG9 alpha-1,2-mannosyltransferase	Sometimes (5–29%)	In 1 condition
CUX1cut like homeobox 1	Sometimes (5–29%)	In 1 condition
DSTdystonin	Sometimes (5–29%)	In 1 condition
GRIN1glutamate ionotropic receptor NMDA type subunit 1	Sometimes (5–29%)	In 1 condition
KIFBPkinesin family binding protein	Sometimes (5–29%)	In 1 condition
MPDU1mannose-P-dolichol utilization defect 1	Sometimes (5–29%)	In 1 condition
MTRR5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Sometimes (5–29%)	In 1 condition
PLPBPpyridoxal phosphate binding protein	Sometimes (5–29%)	In 1 condition
RNU2-2RNA, U2 small nuclear 2	Sometimes (5–29%)	In 1 condition
SNRPNsmall nuclear ribonucleoprotein polypeptide N	Sometimes (5–29%)	In 1 condition
WACWW domain containing adaptor with coiled-coil	Sometimes (5–29%)	In 1 condition
WARS2tryptophanyl tRNA synthetase 2, mitochondrial	Sometimes (5–29%)	In 1 condition
AIFM1apoptosis inducing factor mitochondria associated 1	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormal subarachnoid space morphology

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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