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Trait
Generalized-onset seizure
A generalized-onset seizure is a type of seizure originating at some point within, and rapidly engaging, bilaterally distributed networks. The networks may include cortical and subcortical structures but not necessarily the entire cortex.
Summary
- Also called
- Generalised onset seizure, Generalised seizures, Generalised-onset seizure, Generalized onset seizure, Generalized seizures, Generalized-onset seizures, Primary generalised seizure, Primary generalized seizure
- Body system
- Abnormality of the nervous system
Generalized-onset seizureHP:0002197
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Read the genes linked to Generalized-onset seizure, and the rest of your genome, with one test.
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Get my Genome Test129 genes linked to Generalized-onset seizure
Changes in these genes cause rare conditions in which Generalized-onset seizure is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATP1A1ATPase Na+/K+ transporting subunit alpha 1 | Always | In 2 conditions |
| COL4A2collagen type IV alpha 2 chain | Always | In 1 condition |
| CRELD1CRELD disulfide isomerase 1 | Always | In 1 condition |
| DDX59DEAD-box helicase 59 | Always | In 1 condition |
| EHMT1euchromatic histone lysine methyltransferase 1 | Always | In 1 condition |
| EPG5ectopic P-granules 5 autophagy tethering factor | Always | In 1 condition |
| GLULglutamate-ammonia ligase | Always | In 1 condition |
| GPHNgephyrin | Always | In 1 condition |
| GTPBP2GTP binding protein 2 | Always | In 1 condition |
| HECW2HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 | Always | In 1 condition |
| NFU1NFU1 iron-sulfur cluster scaffold | Always | In 1 condition |
| NIT1nitrilase 1 | Always | In 1 condition |
| PI4K2Aphosphatidylinositol 4-kinase type 2 alpha | Always | In 1 condition |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Always | In 1 condition |
| PTPMT1protein tyrosine phosphatase mitochondrial 1 | Always | In 1 condition |
| PUM1pumilio RNA binding family member 1 | Always | In 1 condition |
| RRP12ribosomal RNA processing 12 homolog | Always | In 1 condition |
| SEC31ASEC31 homolog A, COPII component | Always | In 1 condition |
| SLC32A1solute carrier family 32 member 1 | Always | In 2 conditions |
| SUCLA2succinate-CoA ligase ADP-forming subunit beta | Always | In 1 condition |
| YARS1tyrosyl-tRNA synthetase 1 | Always | In 1 condition |
| ADGRV1adhesion G protein-coupled receptor V1 | Very often (80–99%) | In 1 condition |
| APC2APC regulator of Wnt signaling pathway 2 | Very often (80–99%) | In 1 condition |
| CACNB4calcium voltage-gated channel auxiliary subunit beta 4 | Very often (80–99%) | In 1 condition |
| CILK1ciliogenesis associated kinase 1 | Very often (80–99%) | In 1 condition |
| CLCN2chloride voltage-gated channel 2 | Very often (80–99%) | In 1 condition |
| CPA6carboxypeptidase A6 | Very often (80–99%) | In 1 condition |
| EFHC1EF-hand domain containing 1 | Very often (80–99%) | In 2 conditions |
| FGF13fibroblast growth factor 13 | Very often (80–99%) | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Very often (80–99%) | In 1 condition |
| GABRA1gamma-aminobutyric acid type A receptor subunit alpha1 | Very often (80–99%) | In 1 condition |
| GABRDgamma-aminobutyric acid type A receptor subunit delta | Very often (80–99%) | In 2 conditions |
| GABRG2gamma-aminobutyric acid type A receptor subunit gamma2 | Very often (80–99%) | In 1 condition |
| HCN1hyperpolarization activated cyclic nucleotide gated potassium channel 1 | Very often (80–99%) | In 1 condition |
| JRKJrk helix-turn-helix protein | Very often (80–99%) | In 1 condition |
| KCNJ10potassium inwardly rectifying channel subfamily J member 10 | Very often (80–99%) | In 1 condition |
| KCNQ3potassium voltage-gated channel subfamily Q member 3 | Very often (80–99%) | In 1 condition |
| PRRT2proline rich transmembrane protein 2 | Very often (80–99%) | In 2 conditions |
| SCN1Asodium voltage-gated channel alpha subunit 1 | Very often (80–99%) | In 1 condition |
| SCN1Bsodium voltage-gated channel beta subunit 1 | Very often (80–99%) | In 1 condition |
Show 89 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SCN2Asodium voltage-gated channel alpha subunit 2 | Very often (80–99%) | In 1 condition |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Very often (80–99%) | In 1 condition |
| SLC9A6solute carrier family 9 member A6 | Very often (80–99%) | In 1 condition |
| STX1Bsyntaxin 1B | Very often (80–99%) | In 1 condition |
| SYNGAP1synaptic Ras GTPase activating protein 1 | Very often (80–99%) | In 1 condition |
| ADRA2Badrenoceptor alpha 2B | Often (30–79%) | In 1 condition |
| AIFM1apoptosis inducing factor mitochondria associated 1 | Often (30–79%) | In 1 condition |
| ALDH4A1aldehyde dehydrogenase 4 family member A1 | Often (30–79%) | In 1 condition |
| ANO10anoctamin 10 | Often (30–79%) | In 1 condition |
| APOEapolipoprotein E | Often (30–79%) | In 1 condition |
| ATXN10ataxin 10 | Often (30–79%) | In 1 condition |
| AVPR2arginine vasopressin receptor 2 | Often (30–79%) | In 1 condition |
| BCKDKbranched chain keto acid dehydrogenase kinase | Often (30–79%) | In 1 condition |
| C1GALT1C1C1GALT1 specific chaperone 1 | Often (30–79%) | In 1 condition |
| CDKL5cyclin dependent kinase like 5 | Often (30–79%) | In 1 condition |
| CNTN2contactin 2 | Often (30–79%) | In 1 condition |
| CPLX1complexin 1 | Often (30–79%) | In 1 condition |
| CST3cystatin C | Often (30–79%) | In 1 condition |
| CTNND2catenin delta 2 | Often (30–79%) | In 1 condition |
| DCXdoublecortin | Often (30–79%) | In 1 condition |
| DOHHdeoxyhypusine hydroxylase | Often (30–79%) | In 1 condition |
| EXTL3exostosin like glycosyltransferase 3 | Often (30–79%) | In 2 conditions |
| FRYLFRY like transcription coactivator | Often (30–79%) | In 1 condition |
| FTLferritin light chain | Often (30–79%) | In 1 condition |
| GLUD1glutamate dehydrogenase 1 | Often (30–79%) | In 1 condition |
| GOSR2golgi SNAP receptor complex member 2 | Often (30–79%) | In 1 condition |
| GRIN1glutamate ionotropic receptor NMDA type subunit 1 | Often (30–79%) | In 1 condition |
| GRIN2Dglutamate ionotropic receptor NMDA type subunit 2D | Often (30–79%) | In 1 condition |
| IER3IP1immediate early response 3 interacting protein 1 | Often (30–79%) | In 1 condition |
| KCNMA1potassium calcium-activated channel subfamily M alpha 1 | Often (30–79%) | In 1 condition |
| KPTNkaptin, actin binding protein | Often (30–79%) | In 1 condition |
| MARCHF6membrane associated ring-CH-type finger 6 | Often (30–79%) | In 1 condition |
| MTORmechanistic target of rapamycin kinase | Often (30–79%) | In 1 condition |
| MTR5-methyltetrahydrofolate-homocysteine methyltransferase | Often (30–79%) | In 1 condition |
| MYCNMYCN proto-oncogene, bHLH transcription factor | Often (30–79%) | In 1 condition |
| NDUFA13NADH:ubiquinone oxidoreductase subunit A13 | Often (30–79%) | In 1 condition |
| PLAAphospholipase A2 activating protein | Often (30–79%) | In 1 condition |
| PMM2phosphomannomutase 2 | Often (30–79%) | In 1 condition |
| PPFIBP1PPFIB scaffold protein 1 | Often (30–79%) | In 1 condition |
| PPP3CAprotein phosphatase 3 catalytic subunit alpha | Often (30–79%) | In 1 condition |
| PSEN2presenilin 2 | Often (30–79%) | In 1 condition |
| RAB11BRAB11B, member RAS oncogene family | Often (30–79%) | In 1 condition |
| RAPGEF2Rap guanine nucleotide exchange factor 2 | Often (30–79%) | In 1 condition |
| RARS2arginyl-tRNA synthetase 2, mitochondrial | Often (30–79%) | In 1 condition |
| SAMD12sterile alpha motif domain containing 12 | Often (30–79%) | In 1 condition |
| SLC1A4solute carrier family 1 member 4 | Often (30–79%) | In 1 condition |
| SLC25A12solute carrier family 25 member 12 | Often (30–79%) | In 1 condition |
| SONSON DNA and RNA binding protein | Often (30–79%) | In 1 condition |
| SPOUT1SPOUT domain containing methyltransferase 1 | Often (30–79%) | In 1 condition |
| TNRC6Atrinucleotide repeat containing adaptor 6A | Often (30–79%) | In 1 condition |
| TUBB2Btubulin beta 2B class IIb | Often (30–79%) | In 1 condition |
| UNC13Aunc-13 homolog A | Often (30–79%) | In 1 condition |
| YEATS2YEATS domain containing 2 | Often (30–79%) | In 1 condition |
| AARS1alanyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| CARS1cysteinyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| CEP85Lcentrosomal protein 85L | Sometimes (5–29%) | In 1 condition |
| CLPBClpB family mitochondrial disaggregase | Sometimes (5–29%) | In 1 condition |
| DBR1debranching RNA lariats 1 | Sometimes (5–29%) | In 1 condition |
| ELFN1extracellular leucine rich repeat and fibronectin type III domain containing 1 | Sometimes (5–29%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 1 condition |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 1 condition |
| GTF2E2general transcription factor IIE subunit 2 | Sometimes (5–29%) | In 1 condition |
| GTF2H5general transcription factor IIH subunit 5 | Sometimes (5–29%) | In 1 condition |
| GUCY1A1guanylate cyclase 1 soluble subunit alpha 1 | Sometimes (5–29%) | In 1 condition |
| LRPPRCleucine rich pentatricopeptide repeat containing | Sometimes (5–29%) | In 1 condition |
| MAPK1mitogen-activated protein kinase 1 | Sometimes (5–29%) | In 1 condition |
| MBOAT7membrane bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 | Sometimes (5–29%) | In 1 condition |
| MPLKIPM-phase specific PLK1 interacting protein | Sometimes (5–29%) | In 1 condition |
| NAA10N-alpha-acetyltransferase 10, NatA catalytic subunit | Sometimes (5–29%) | In 1 condition |
| PEX2peroxisomal biogenesis factor 2 | Sometimes (5–29%) | In 1 condition |
| PIDD1p53-induced death domain protein 1 | Sometimes (5–29%) | In 1 condition |
| PLP1proteolipid protein 1 | Sometimes (5–29%) | In 1 condition |
| PPP2R5Cprotein phosphatase 2 regulatory subunit B'gamma | Sometimes (5–29%) | In 1 condition |
| PRORPprotein only RNase P catalytic subunit | Sometimes (5–29%) | In 1 condition |
| RNF113Aring finger protein 113A | Sometimes (5–29%) | In 1 condition |
| RNU2-2RNA, U2 small nuclear 2 | Sometimes (5–29%) | In 1 condition |
| SETBP1SET binding protein 1 | Sometimes (5–29%) | In 1 condition |
| TARS1threonyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Sometimes (5–29%) | In 1 condition |
| WDR62WD repeat domain 62 | Sometimes (5–29%) | In 1 condition |
| LGI1leucine rich glioma inactivated 1 | Rarely (1–4%) | In 1 condition |
| MICAL1microtubule associated monooxygenase, calponin and LIM domain containing 1 | Rarely (1–4%) | In 1 condition |
| RELNreelin | Rarely (1–4%) | In 2 conditions |
| ASAH1N-acylsphingosine amidohydrolase 1 | Not recorded | In 1 condition |
| CNTNAP2contactin associated protein 2 | Not recorded | In 1 condition |
| OSTM1osteoclastogenesis associated transmembrane protein 1 | Not recorded | In 1 condition |
| SCARB2scavenger receptor class B member 2 | Not recorded | In 1 condition |
| SZT2SZT2 subunit of KICSTOR complex | Not recorded | In 1 condition |
| XKX-linked Kx blood group antigen, Kell and VPS13A binding protein | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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Log InAskGet Startedfrom $449
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