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Trait

Interictal EEG abnormality

Interictal refers to a period of time between epileptic seizures. Electroencephalographic (EEG) patterns are important in the differential diagnosis of epilepsy, and the EEG is almost always abnormal during a seizure. Some persons with seizures may show EEG abnormalities between seizures, while others do not. In some cases, multiple interictal EEGs must be recorded before an abnormality is observed. In most cases the electrographic pattern of seizure onset is completely different from the activity recorded during interictal discharge.

HPO HP:0025373

Summary

Body system
Abnormality of the nervous system

29 genes linked to Interictal EEG abnormality

Changes in these genes cause rare conditions in which Interictal EEG abnormality is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
ABCB7ATP binding cassette subfamily B member 7AlwaysIn 1 condition
ELFN1extracellular leucine rich repeat and fibronectin type III domain containing 1AlwaysIn 1 condition
EPG5ectopic P-granules 5 autophagy tethering factorAlwaysIn 1 condition
GYS1glycogen synthase 1AlwaysIn 1 condition
MDGA2MAM domain containing glycosylphosphatidylinositol anchor 2AlwaysIn 1 condition
MMADHCmetabolism of cobalamin associated DAlwaysIn 1 condition
RNU2-2RNA, U2 small nuclear 2AlwaysIn 1 condition
SLC2A1solute carrier family 2 member 1AlwaysIn 1 condition
SV2Asynaptic vesicle glycoprotein 2AAlwaysIn 1 condition
AKT3AKT serine/threonine kinase 3Very often (80–99%)In 1 condition
GRIN2Aglutamate ionotropic receptor NMDA type subunit 2AVery often (80–99%)In 1 condition
KLHL20kelch like family member 20Very often (80–99%)In 1 condition
MTORmechanistic target of rapamycin kinaseVery often (80–99%)In 1 condition
PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaVery often (80–99%)In 1 condition
PPP2R5Cprotein phosphatase 2 regulatory subunit B'gammaVery often (80–99%)In 1 condition
CD274CD274 moleculeOften (30–79%)In 1 condition
CPLX1complexin 1Often (30–79%)In 1 condition
DEPDC5DEP domain containing 5, GATOR1 subcomplex subunitOften (30–79%)In 1 condition
FDXRferredoxin reductaseOften (30–79%)In 1 condition
NDC1NDC1 transmembrane nucleoporinOften (30–79%)In 1 condition
NPRL2NPR2 like, GATOR1 complex subunitOften (30–79%)In 1 condition
NPRL3NPR3 like, GATOR1 complex subunitOften (30–79%)In 1 condition
RNF13ring finger protein 13Often (30–79%)In 1 condition
SCN3Asodium voltage-gated channel alpha subunit 3Often (30–79%)In 1 condition
SCN8Asodium voltage-gated channel alpha subunit 8Often (30–79%)In 1 condition
TBC1D24TBC1 domain family member 24Often (30–79%)In 1 condition
TRA2Btransformer 2 beta homologOften (30–79%)In 1 condition
UGGT1UDP-glucose glycoprotein glucosyltransferase 1Often (30–79%)In 1 condition
SPOUT1SPOUT domain containing methyltransferase 1Sometimes (5–29%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

EEG abnormality

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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