Trait
Decreased facial expressions
Clinical name: Hypomimic face
A reduced degree of motion of the muscles beneath the skin of the face, often associated with reduced facial crease formation.
Summary
- Also called
- Decreased facial muscle movement, Dull facial expression, Hypomimia
Reference genomeGRCh38hg38
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Get my Genome Test41 genes linked to Decreased facial expressions
Changes in these genes cause rare conditions in which Decreased facial expressions is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATCAYATCAY kinesin light chain interacting caytaxin | Always | In 1 condition |
| DNAJC6DnaJ heat shock protein family (Hsp40) member C6 | Always | In 2 conditions |
| MYMXmyomixer, myoblast fusion factor | Always | In 1 condition |
| PPFIA3PPFI scaffold protein A3 | Always | In 1 condition |
| RNU2-2RNA, U2 small nuclear 2 | Always | In 1 condition |
| SLC18A2solute carrier family 18 member A2 | Always | In 2 conditions |
| SLC6A3solute carrier family 6 member 3 | Always | In 2 conditions |
| TECPR2tectonin beta-propeller repeat containing 2 | Always | In 2 conditions |
| ATP6AP2ATPase H+ transporting accessory protein 2 | Very often (80–99%) | In 3 conditions |
| PODXLpodocalyxin like | Very often (80–99%) | In 1 condition |
| SYNJ1synaptojanin 1 | Very often (80–99%) | In 1 condition |
| ATP13A2ATPase cation transporting 13A2 | Often (30–79%) | In 1 condition |
| ATP1A3ATPase Na+/K+ transporting subunit alpha 3 | Often (30–79%) | In 2 conditions |
| CNTNAP1contactin associated protein 1 | Often (30–79%) | In 1 condition |
| FBXO7F-box protein 7 | Often (30–79%) | In 2 conditions |
| FTLferritin light chain | Often (30–79%) | In 2 conditions |
| KCNK9potassium two pore domain channel subfamily K member 9 | Often (30–79%) | In 1 condition |
| PLA2G6phospholipase A2 group VI | Often (30–79%) | In 2 conditions |
| POLGDNA polymerase gamma, catalytic subunit | Often (30–79%) | In 1 condition |
| POLG2DNA polymerase gamma 2, accessory subunit | Often (30–79%) | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Often (30–79%) | In 1 condition |
| SLC25A4solute carrier family 25 member 4 | Often (30–79%) | In 1 condition |
| SLC30A10solute carrier family 30 member 10 | Often (30–79%) | In 1 condition |
| SLC39A14solute carrier family 39 member 14 | Often (30–79%) | In 2 conditions |
| SNCAsynuclein alpha | Often (30–79%) | In 2 conditions |
| SPRsepiapterin reductase | Often (30–79%) | In 1 condition |
| TWNKtwinkle mtDNA helicase | Often (30–79%) | In 1 condition |
| WARS2tryptophanyl tRNA synthetase 2, mitochondrial | Often (30–79%) | In 1 condition |
| CLTCclathrin heavy chain | Sometimes (5–29%) | In 1 condition |
| DDHD2DDHD domain containing 2 | Sometimes (5–29%) | In 1 condition |
| DNAJC13DnaJ heat shock protein family (Hsp40) member C13 | Sometimes (5–29%) | In 1 condition |
| EIF4G1eukaryotic translation initiation factor 4 gamma 1 | Sometimes (5–29%) | In 1 condition |
| GBA1glucosylceramidase beta 1 | Sometimes (5–29%) | In 1 condition |
| GIGYF2GRB10 interacting GYF protein 2 | Sometimes (5–29%) | In 1 condition |
| JAM2junctional adhesion molecule 2 | Sometimes (5–29%) | In 1 condition |
| LRRK2leucine rich repeat kinase 2 | Sometimes (5–29%) | In 1 condition |
| PRDX3peroxiredoxin 3 | Sometimes (5–29%) | In 1 condition |
| VPS35VPS35 retromer complex component | Sometimes (5–29%) | In 1 condition |
| CC2D1Acoiled-coil and C2 domain containing 1A | Not recorded | In 1 condition |
| PLAAphospholipase A2 activating protein | Not recorded | In 1 condition |
Show 1 more gene
| Gene | How often it is seen | Conditions |
|---|---|---|
| TXNL4Athioredoxin like 4A | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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