Trait
Persistent head lag
The Premie-Neuro and the Dubowitz Neurological Examination score head lag in the same manner. Scoring for both is as follows: 0 = head drops and stays back, 1 = tries to lift head but drops it back, 2 = able to lift head slightly, 3 = lifts head in line with body, and 4 = head in front of body. This term applies if head lag persists beyond an expected age at a level of 0 or 1. Persistent head lag beyond age 4 mo has been linked to poor outcomes.
Summary
- Also called
- Head lag, Headlag
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test37 genes linked to Persistent head lag
Changes in these genes cause rare conditions in which Persistent head lag is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CDK5cyclin dependent kinase 5 | Always | In 1 condition |
| COX10cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 | Always | In 1 condition |
| DOT1LDOT1 like histone lysine methyltransferase | Always | In 1 condition |
| EN1engrailed homeobox 1 | Always | In 1 condition |
| FARSBphenylalanyl-tRNA synthetase subunit beta | Always | In 1 condition |
| IFT140intraflagellar transport 140 | Always | In 1 condition |
| ITPR1inositol 1,4,5-trisphosphate receptor type 1 | Always | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Always | In 1 condition |
| MICOS13mitochondrial contact site and cristae organizing system subunit 13 | Always | In 1 condition |
| MMABmetabolism of cobalamin associated B | Always | In 1 condition |
| MOCS3molybdenum cofactor synthesis 3 | Always | In 1 condition |
| MPZmyelin protein zero | Always | In 1 condition |
| NONOnon-POU domain containing octamer binding | Always | In 1 condition |
| RFC4replication factor C subunit 4 | Always | In 1 condition |
| RNH1ribonuclease/angiogenin inhibitor 1 | Always | In 1 condition |
| RNU2-2RNA, U2 small nuclear 2 | Always | In 1 condition |
| SERPINH1serpin family H member 1 | Always | In 1 condition |
| SLC31A1solute carrier family 31 member 1 | Always | In 1 condition |
| SUCLG1succinate-CoA ligase GDP/ADP-forming subunit alpha | Always | In 1 condition |
| UBA1ubiquitin like modifier activating enzyme 1 | Always | In 1 condition |
| UGP2UDP-glucose pyrophosphorylase 2 | Always | In 1 condition |
| DLATdihydrolipoamide S-acetyltransferase | Often (30–79%) | In 1 condition |
| GEMIN4gem nuclear organelle associated protein 4 | Often (30–79%) | In 1 condition |
| LINS1lines homolog 1 | Often (30–79%) | In 1 condition |
| LYRM4LYR motif containing 4 | Often (30–79%) | In 1 condition |
| MYL1myosin light chain 1 | Often (30–79%) | In 1 condition |
| SLC25A12solute carrier family 25 member 12 | Often (30–79%) | In 1 condition |
| CAMK2Bcalcium/calmodulin dependent protein kinase II beta | Sometimes (5–29%) | In 1 condition |
| CRELD1CRELD disulfide isomerase 1 | Sometimes (5–29%) | In 1 condition |
| DHX30DExH-box helicase 30 | Sometimes (5–29%) | In 1 condition |
| LAMB2laminin subunit beta 2 | Sometimes (5–29%) | In 1 condition |
| NAA20N-alpha-acetyltransferase 20, NatB catalytic subunit | Sometimes (5–29%) | In 1 condition |
| NEDD4LNEDD4 like E3 ubiquitin protein ligase | Sometimes (5–29%) | In 1 condition |
| NSRP1nuclear speckle splicing regulatory protein 1 | Sometimes (5–29%) | In 1 condition |
| TIMM50translocase of inner mitochondrial membrane 50 | Sometimes (5–29%) | In 1 condition |
| UGGT1UDP-glucose glycoprotein glucosyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| SPTBN1spectrin beta, non-erythrocytic 1 | Rarely (1–4%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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