Trait
Clouding of the lens of the eye at birth
Clinical name: Developmental cataract
A cataract that occurs congenitally as the result of a developmental defect, in contrast to the majority of cataracts that occur in adulthood as the result of degenerative changes of the lens.
Summary
- Also called
- Bilateral congenital cataracts, Cataract, congenital, Congenital cataract, Congenital cataracts, Congenital cataracts, bilateral
- Body system
- Abnormality of the eye
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Clouding of the lens of the eye at birth, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test159 genes linked to Clouding of the lens of the eye at birth
Changes in these genes cause rare conditions in which Clouding of the lens of the eye at birth is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AGKacylglycerol kinase | Always | In 2 conditions |
| BCORBCL6 corepressor | Always | In 1 condition |
| CRYGBcrystallin gamma B | Always | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Always | In 2 conditions |
| GTF2H5general transcription factor IIH subunit 5 | Always | In 2 conditions |
| HMX1H6 family homeobox 1 | Always | In 1 condition |
| HYCC1hyccin PI4KA lipid kinase complex subunit 1 | Always | In 2 conditions |
| KCNA4potassium voltage-gated channel subfamily A member 4 | Always | In 1 condition |
| LSSlanosterol synthase | Always | In 1 condition |
| MED16mediator complex subunit 16 | Always | In 1 condition |
| MSMO1methylsterol monooxygenase 1 | Always | In 1 condition |
| NUP188nucleoporin 188 | Always | In 1 condition |
| PEX11Bperoxisomal biogenesis factor 11 beta | Always | In 1 condition |
| PEX5peroxisomal biogenesis factor 5 | Always | In 1 condition |
| PIGYphosphatidylinositol glycan anchor biosynthesis class Y | Always | In 1 condition |
| PIK3C2Aphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha | Always | In 2 conditions |
| PITX3paired like homeodomain 3 | Always | In 1 condition |
| PSMC3proteasome 26S subunit, ATPase 3 | Always | In 1 condition |
| RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1 | Always | In 2 conditions |
| RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2 | Always | In 2 conditions |
| SEC31ASEC31 homolog A, COPII component | Always | In 1 condition |
| SIL1SIL1 nucleotide exchange factor | Always | In 1 condition |
| SLC33A1solute carrier family 33 member 1 | Always | In 1 condition |
| SUPT7LSPT7 like, STAGA complex subunit gamma | Always | In 1 condition |
| TBC1D20TBC1 domain family member 20 | Always | In 1 condition |
| CHD6chromodomain helicase DNA binding protein 6 | Very often (80–99%) | In 1 condition |
| IARS2isoleucyl-tRNA synthetase 2, mitochondrial | Very often (80–99%) | In 1 condition |
| MAFMAF bZIP transcription factor | Very often (80–99%) | In 2 conditions |
| RIC1RIC1 partner of RAB6A GEF complex | Very often (80–99%) | In 1 condition |
| VPS4Avacuolar protein sorting 4 homolog A | Very often (80–99%) | In 1 condition |
| ABCA2ATP binding cassette subfamily A member 2 | Often (30–79%) | In 1 condition |
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Often (30–79%) | In 4 conditions |
| ANAPC1anaphase promoting complex subunit 1 | Often (30–79%) | In 1 condition |
| ATOH7atonal bHLH transcription factor 7 | Often (30–79%) | In 1 condition |
| CAV1caveolin 1 | Often (30–79%) | In 1 condition |
| COL18A1collagen type XVIII alpha 1 chain | Often (30–79%) | In 1 condition |
| DPAGT1dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 | Often (30–79%) | In 1 condition |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Often (30–79%) | In 2 conditions |
| FZD4frizzled class receptor 4 | Often (30–79%) | In 1 condition |
| GFERgrowth factor, augmenter of liver regeneration | Often (30–79%) | In 2 conditions |
Show 119 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| GTPBP2GTP binding protein 2 | Often (30–79%) | In 1 condition |
| LARGE1LARGE xylosyl- and glucuronyltransferase 1 | Often (30–79%) | In 1 condition |
| MED25mediator complex subunit 25 | Often (30–79%) | In 1 condition |
| NDPnorrin cystine knot growth factor NDP | Often (30–79%) | In 1 condition |
| SNUPNsnurportin 1 | Often (30–79%) | In 1 condition |
| TKTtransketolase | Often (30–79%) | In 1 condition |
| AARS1alanyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| ARPC4actin related protein 2/3 complex subunit 4 | Sometimes (5–29%) | In 1 condition |
| ATAD3AATPase family AAA domain containing 3A | Sometimes (5–29%) | In 2 conditions |
| CARS1cysteinyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| CRYABcrystallin alpha B | Sometimes (5–29%) | In 1 condition |
| DBR1debranching RNA lariats 1 | Sometimes (5–29%) | In 1 condition |
| DOCK6dedicator of cytokinesis 6 | Sometimes (5–29%) | In 1 condition |
| ELNelastin | Sometimes (5–29%) | In 1 condition |
| ENTPD1ectonucleoside triphosphate diphosphohydrolase 1 | Sometimes (5–29%) | In 1 condition |
| ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit | Sometimes (5–29%) | In 1 condition |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 1 condition |
| ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit | Sometimes (5–29%) | In 1 condition |
| FAM111AFAM111 trypsin like peptidase A | Sometimes (5–29%) | In 2 conditions |
| FAM177A1family with sequence similarity 177 member A1 | Sometimes (5–29%) | In 1 condition |
| FBLN5fibulin 5 | Sometimes (5–29%) | In 1 condition |
| GTF2E2general transcription factor IIE subunit 2 | Sometimes (5–29%) | In 1 condition |
| HSPG2heparan sulfate proteoglycan 2 | Sometimes (5–29%) | In 1 condition |
| IDH1isocitrate dehydrogenase (NADP(+)) 1 | Sometimes (5–29%) | In 1 condition |
| KCTD1potassium channel tetramerization domain containing 1 | Sometimes (5–29%) | In 1 condition |
| LMNAlamin A/C | Sometimes (5–29%) | In 1 condition |
| MAFAMAF bZIP transcription factor A | Sometimes (5–29%) | In 1 condition |
| MPLKIPM-phase specific PLK1 interacting protein | Sometimes (5–29%) | In 1 condition |
| NAA60N-alpha-acetyltransferase 60, NatF catalytic subunit | Sometimes (5–29%) | In 1 condition |
| NEU1neuraminidase 1 | Sometimes (5–29%) | In 1 condition |
| PHGDHphosphoglycerate dehydrogenase | Sometimes (5–29%) | In 2 conditions |
| PNPT1polyribonucleotide nucleotidyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| POMT1protein O-mannosyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| RECQL4RecQ like helicase 4 | Sometimes (5–29%) | In 1 condition |
| RNF113Aring finger protein 113A | Sometimes (5–29%) | In 1 condition |
| SMC5structural maintenance of chromosomes 5 | Sometimes (5–29%) | In 1 condition |
| TARS1threonyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| TELO2telomere maintenance 2 | Sometimes (5–29%) | In 1 condition |
| UBE2Aubiquitin conjugating enzyme E2 A | Sometimes (5–29%) | In 1 condition |
| ADA2adenosine deaminase 2 | Rarely (1–4%) | In 1 condition |
| COL4A1collagen type IV alpha 1 chain | Rarely (1–4%) | In 1 condition |
| EHMT1euchromatic histone lysine methyltransferase 1 | Rarely (1–4%) | In 1 condition |
| GATA1GATA binding protein 1 | Rarely (1–4%) | In 1 condition |
| HEATR3HEAT repeat containing 3 | Rarely (1–4%) | In 1 condition |
| KMT2Clysine methyltransferase 2C | Rarely (1–4%) | In 1 condition |
| RPL11ribosomal protein L11 | Rarely (1–4%) | In 1 condition |
| RPL15ribosomal protein L15 | Rarely (1–4%) | In 1 condition |
| RPL18ribosomal protein L18 | Rarely (1–4%) | In 1 condition |
| RPL26ribosomal protein L26 | Rarely (1–4%) | In 1 condition |
| RPL27ribosomal protein L27 | Rarely (1–4%) | In 1 condition |
| RPL31ribosomal protein L31 | Rarely (1–4%) | In 1 condition |
| RPL35ribosomal protein L35 | Rarely (1–4%) | In 1 condition |
| RPL35Aribosomal protein L35a | Rarely (1–4%) | In 1 condition |
| RPL5ribosomal protein L5 | Rarely (1–4%) | In 1 condition |
| RPL8ribosomal protein L8 | Rarely (1–4%) | In 1 condition |
| RPL9ribosomal protein L9 | Rarely (1–4%) | In 1 condition |
| RPS10ribosomal protein S10 | Rarely (1–4%) | In 1 condition |
| RPS15Aribosomal protein S15a | Rarely (1–4%) | In 1 condition |
| RPS17ribosomal protein S17 | Rarely (1–4%) | In 1 condition |
| RPS19ribosomal protein S19 | Rarely (1–4%) | In 1 condition |
| RPS20ribosomal protein S20 | Rarely (1–4%) | In 1 condition |
| RPS24ribosomal protein S24 | Rarely (1–4%) | In 1 condition |
| RPS26ribosomal protein S26 | Rarely (1–4%) | In 1 condition |
| RPS27ribosomal protein S27 | Rarely (1–4%) | In 1 condition |
| RPS28ribosomal protein S28 | Rarely (1–4%) | In 1 condition |
| RPS29ribosomal protein S29 | Rarely (1–4%) | In 1 condition |
| RPS7ribosomal protein S7 | Rarely (1–4%) | In 1 condition |
| TSR2TSR2 ribosome maturation factor | Rarely (1–4%) | In 1 condition |
| BEST1bestrophin 1 | Not recorded | In 1 condition |
| BFSP2beaded filament structural protein 2 | Not recorded | In 1 condition |
| COL4A3collagen type IV alpha 3 chain | Not recorded | In 1 condition |
| COL4A4collagen type IV alpha 4 chain | Not recorded | In 1 condition |
| COL4A5collagen type IV alpha 5 chain | Not recorded | In 1 condition |
| CRYAAcrystallin alpha A | Not recorded | In 1 condition |
| CRYBA1crystallin beta A1 | Not recorded | In 1 condition |
| CRYBA2crystallin beta A2 | Not recorded | In 1 condition |
| CRYBB1crystallin beta B1 | Not recorded | In 1 condition |
| CRYBB2crystallin beta B2 | Not recorded | In 1 condition |
| CRYBB3crystallin beta B3 | Not recorded | In 1 condition |
| CRYGCcrystallin gamma C | Not recorded | In 1 condition |
| CRYGDcrystallin gamma D | Not recorded | In 1 condition |
| CTDP1CTD phosphatase 1 | Not recorded | In 1 condition |
| EPG5ectopic P-granules 5 autophagy tethering factor | Not recorded | In 1 condition |
| EPHA2EPH receptor A2 | Not recorded | In 1 condition |
| ETFAelectron transfer flavoprotein subunit alpha | Not recorded | In 1 condition |
| ETFBelectron transfer flavoprotein subunit beta | Not recorded | In 1 condition |
| ETFDHelectron transfer flavoprotein dehydrogenase | Not recorded | In 1 condition |
| GCNT2glucosaminyl (N-acetyl) transferase 2 (I blood group) | Not recorded | In 1 condition |
| KIF1Bkinesin family member 1B | Not recorded | In 1 condition |
| LONP1lon peptidase 1, mitochondrial | Not recorded | In 1 condition |
| MAXMYC associated transcriptional regulator X | Not recorded | In 1 condition |
| MIR204microRNA 204 | Not recorded | In 1 condition |
| MT-CO1mitochondrially encoded cytochrome c oxidase I | Not recorded | In 1 condition |
| MT-CO2mitochondrially encoded cytochrome c oxidase II | Not recorded | In 1 condition |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Not recorded | In 1 condition |
| MT-CYBmitochondrially encoded cytochrome b | Not recorded | In 1 condition |
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Not recorded | In 1 condition |
| MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Not recorded | In 1 condition |
| MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Not recorded | In 1 condition |
| MT-TCmitochondrially encoded tRNA-Cys (UGU/C) | Not recorded | In 1 condition |
| MT-TFmitochondrially encoded tRNA-Phe (UUU/C) | Not recorded | In 1 condition |
| MT-THmitochondrially encoded tRNA-His (CAU/C) | Not recorded | In 1 condition |
| MT-TKmitochondrially encoded tRNA-Lys (AAA/G) | Not recorded | In 1 condition |
| MT-TL1mitochondrially encoded tRNA-Leu (UUA/G) 1 | Not recorded | In 1 condition |
| MT-TL2mitochondrially encoded tRNA-Leu (CUN) 2 | Not recorded | In 1 condition |
| MT-TQmitochondrially encoded tRNA-Gln (CAA/G) | Not recorded | In 1 condition |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Not recorded | In 1 condition |
| MT-TS2mitochondrially encoded tRNA-Ser (AGU/C) 2 | Not recorded | In 1 condition |
| MT-TVmitochondrially encoded tRNA-Val (GUN) | Not recorded | In 1 condition |
| MT-TWmitochondrially encoded tRNA-Trp (UGA/G) | Not recorded | In 1 condition |
| NHSNHS actin remodeling regulator | Not recorded | In 1 condition |
| OCRLOCRL inositol polyphosphate-5-phosphatase | Not recorded | In 1 condition |
| PAX6paired box 6 | Not recorded | In 1 condition |
| PEX7peroxisomal biogenesis factor 7 | Not recorded | In 1 condition |
| RAB18RAB18, member RAS oncogene family | Not recorded | In 1 condition |
| RETret proto-oncogene | Not recorded | In 1 condition |
| SIPA1L3signal induced proliferation associated 1 like 3 | Not recorded | In 1 condition |
| TMEM127transmembrane protein 127 | Not recorded | In 1 condition |
| VHLvon Hippel-Lindau tumor suppressor | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks