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Gene

CRYBA2

crystallin beta A2

Summary

Cytogenetic location
2q35
Coordinates
Chromosome 2: 218,990,190–218,993,422 (GRCh38)
Exons
4 exons across 3.2 kb
Protein
197 amino acids
MANE Select transcript
ENST00000295728.7NM_057093.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Congenital & Juvenile Cataract

    • Early-Onset Non-Syndromic Cataract

      Cataract that appears at birth or early in life without other features, caused by changes in lens genes such as the crystallins (CRYAA, CRYBB2, CRYGD and others), GJA3, GJA8 and MIP.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Early detection and surgery in children help prevent permanent vision loss from amblyopia, and family members can be offered eye checks.

How CRYBA2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 2, with a bracket where CRYBA2 sits. CRYBA2 and 36 genes near it on chromosome 2, from 218,491,806 to 219,491,805.Chromosome 22q35p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3218.6 Mb218.8 Mb219 Mb219.2 Mb219.4 MbUSP37: 218,450,251–218,568,768, reverse strandUSP37CNOT9: 218,568,575–218,597,080, forward strandCNOT9PLCD4: 218,607,855–218,637,186, forward strandPLCD4ZNF142: 218,633,329–218,659,655, reverse strandZNF142BCS1L: 218,658,764–218,668,759, forward strandBCS1LRNF25: 218,662,081–218,672,009, reverse strandRNF25STK36: 218,672,027–218,702,717, forward strandSTK36TTLL4: 218,710,773–218,759,724, forward strandTTLL4CYP27A1: 218,781,688–218,825,335, forward strandCYP27A1PRKAG3: 218,819,050–218,832,086, reverse strandPRKAG3WNT6: 218,859,795–218,874,233, forward strandWNT6WNT10A: 218,880,852–218,899,581, forward strandWNT10ACDK5R2: 218,959,666–218,962,155, forward strandCDK5R2FEV: 218,981,087–218,985,566, reverse strandFEVCRYBA2: 218,990,190–218,993,422, reverse strandCRYBA2CFAP65: 219,002,846–219,041,527, reverse strandCFAP65IHH: 219,054,424–219,061,064, reverse strandIHHNHEJ1: 219,069,355–219,160,869, reverse strandNHEJ1: 219,075,329–219,170,827, reverse strandSLC23A3: 219,161,465–219,170,095, reverse strandSLC23A3CNPPD1: 219,170,704–219,182,664, reverse strandCNPPD1RETREG2: 219,176,225–219,185,917, forward strandZFAND2B: 219,195,237–219,209,651, forward strandABCB6: 219,209,765–219,219,012, reverse strandABCB6: 219,209,772–219,222,738, reverse strandATG9A: 219,219,380–219,230,383, reverse strandANKZF1: 219,229,769–219,236,679, forward strandGLB1L: 219,236,598–219,245,478, reverse strandGLB1LSTK16: 219,245,212–219,250,339, forward strandTUBA4A: 219,249,710–219,277,902, reverse strandTUBA4B: 219,253,243–219,272,197, forward strandDNAJB2: 219,279,308–219,286,900, forward strandDNAJB2PTPRN: 219,289,623–219,309,648, reverse strandPTPRNRESP18: 219,327,407–219,335,552, reverse strandRESP18DNPEP: 219,360,090–219,400,022, reverse strandDNPEPDES: 219,417,474–219,426,740, forward strandDESSPEG: 219,434,471–219,493,629, forward strandSPEGDiagram of CRYBA2: 4 exons on the reverse strand of chromosome 2Exon 4: 218,990,190–218,990,399, 210 basesExon 3: 218,990,852–218,990,994, 143 basesExon 2: 218,992,102–218,992,243, 142 basesExon 1: 218,993,016–218,993,422, 407 bases43215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.9 kb of the gene's 3.2 kb; 594 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CRYBA2 gene: crystallin beta A2. Retrieved 16 October 2026, from https://dantelabs.com/genes/cryba2

Vancouver

Dante Labs. CRYBA2 gene: crystallin beta A2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cryba2

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