Skip to content
Use your HSA or FSA funds

Gene

CRYBB2

crystallin beta B2

Summary

Cytogenetic location
22q11.23
Coordinates
Chromosome 22: 25,219,639–25,231,869 (GRCh38)
Exons
6 exons across 12.2 kb
Protein
205 amino acids
Previous symbols
CCA2, CRYB2A, CRYB2
MANE Select transcript
ENST00000398215.3NM_000496.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads CRYBB2 yet. The test sequences your whole genome, so your data includes it all the same.

How CRYBB2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 22, with a bracket where CRYBB2 sits. CRYBB2 and 6 genes near it on chromosome 22, from 24,725,754 to 25,725,753.Chromosome 2222q11.23p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3324.8 Mb25 Mb25.2 Mb25.4 Mb25.6 MbPIWIL3: 24,719,034–24,774,720, reverse strandPIWIL3SGSM1: 24,806,067–24,932,150, forward strandSGSM1LHFPL7: 24,935,098–24,946,695, reverse strandLHFPL7KIAA1671: 24,952,643–25,197,448, forward strandKIAA1671CRYBB3: 25,199,858–25,207,359, forward strandCRYBB3CRYBB2: 25,219,639–25,231,869, forward strandCRYBB2GRK3: 25,564,432–25,729,294, forward strandGRK3Diagram of CRYBB2: 6 exons on the forward strand of chromosome 22Exon 3: 2 known disease-causing sitesExon 4: 1 known disease-causing siteExon 5: 3 known disease-causing sitesExon 6: 5 known disease-causing sitesExon 1: 25,219,639–25,219,666, 28 basesExon 2: 25,221,404–25,221,483, 80 basesExon 3: 25,224,918–25,225,036, 119 basesExon 4: 25,227,853–25,227,985, 133 basesExon 5: 25,229,436–25,229,578, 143 basesExon 6: 25,231,604–25,231,869, 266 bases1234565′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.8 kb of the gene's 12.2 kb; 618 of those bases code for the protein.

How a genome test reads CRYBB2

12

positions in CRYBB2 where ClinVar classes a change as pathogenic or likely pathogenic

9 of them (75%) fall in regions short reads find hard.

  • Segmental duplications (9 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 12.2 kb of CRYBB2, introns included, not only the 0.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CRYBB2 gene: crystallin beta B2. Retrieved 17 October 2026, from https://dantelabs.com/genes/crybb2

Vancouver

Dante Labs. CRYBB2 gene: crystallin beta B2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/crybb2

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test