Skip to content
Use your HSA or FSA funds

Gene

CRYBB3

crystallin beta B3

Summary

Cytogenetic location
22q11.23
Coordinates
Chromosome 22: 25,199,858–25,207,359 (GRCh38)
Exons
6 exons across 7.5 kb
Protein
211 amino acids
Previous symbols
CRYB3
MANE Select transcript
ENST00000215855.7NM_004076.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Congenital & Juvenile Cataract

    • Early-Onset Non-Syndromic Cataract

      Cataract that appears at birth or early in life without other features, caused by changes in lens genes such as the crystallins (CRYAA, CRYBB2, CRYGD and others), GJA3, GJA8 and MIP.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Early detection and surgery in children help prevent permanent vision loss from amblyopia, and family members can be offered eye checks.

How CRYBB3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 22, with a bracket where CRYBB3 sits. CRYBB3 and 6 genes near it on chromosome 22, from 24,703,609 to 25,703,608.Chromosome 2222q11.23p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3324.8 Mb25 Mb25.2 Mb25.4 Mb25.6 MbPIWIL3: 24,719,034–24,774,720, reverse strandPIWIL3SGSM1: 24,806,067–24,932,150, forward strandSGSM1LHFPL7: 24,935,098–24,946,695, reverse strandLHFPL7KIAA1671: 24,952,643–25,197,448, forward strandKIAA1671CRYBB3: 25,199,858–25,207,359, forward strandCRYBB3CRYBB2: 25,212,564–25,231,870, forward strandCRYBB2GRK3: 25,564,432–25,729,294, forward strandGRK3Diagram of CRYBB3: 6 exons on the forward strand of chromosome 22Exon 5: 3 known disease-causing sitesExon 1: 25,199,858–25,199,909, 52 basesExon 2: 25,201,377–25,201,471, 95 basesExon 3: 25,202,674–25,202,792, 119 basesExon 4: 25,203,763–25,203,895, 133 basesExon 5: 25,205,220–25,205,362, 143 basesExon 6: 25,207,047–25,207,359, 313 bases1234565′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.9 kb of the gene's 7.5 kb; 636 of those bases code for the protein.

How a genome test reads CRYBB3

5

positions in CRYBB3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 7.5 kb of CRYBB3, introns included, not only the 0.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CRYBB3 gene: crystallin beta B3. Retrieved 16 October 2026, from https://dantelabs.com/genes/crybb3

Vancouver

Dante Labs. CRYBB3 gene: crystallin beta B3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/crybb3

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test