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Gene

STAC3

SH3 and cysteine rich domain 3

Summary

Cytogenetic location
12q13.3
Coordinates
Chromosome 12: 57,243,458–57,251,187 (GRCh38)
Exons
12 exons across 7.7 kb
Protein
364 amino acids
Also known as
MGC2793
MANE Select transcript
ENST00000332782.7NM_145064.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads STAC3 yet. The test sequences your whole genome, so your data includes it all the same.

How STAC3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where STAC3 sits. STAC3 and 36 genes near it on chromosome 12, from 56,747,323 to 57,747,322.Chromosome 1212q13.3p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3356.8 Mb57 Mb57.2 Mb57.4 Mb57.6 MbPRIM1: 56,730,438–56,752,384, reverse strandPRIM1HSD17B6: 56,751,817–56,788,409, forward strandHSD17B6SDR9C7: 56,923,133–56,934,408, reverse strandSDR9C7RDH16: 56,950,087–56,959,374, reverse strandRDH16ACKR5: 56,994,487–56,998,889, forward strandACKR5ZBTB39: 56,998,836–57,006,560, reverse strandZBTB39TAC3: 57,010,000–57,028,883, reverse strandTAC3MYO1A: 57,025,262–57,051,198, reverse strandMYO1ANEMP1: 57,055,641–57,088,063, reverse strandNEMP1NAB2: 57,088,883–57,095,476, forward strandNAB2STAT6: 57,095,403–57,132,139, reverse strandSTAT6LRP1: 57,128,476–57,213,394, forward strandLRP1NXPH4: 57,216,780–57,226,449, forward strandNXPH4SHMT2: 57,226,554–57,234,935, forward strandSHMT2COXFA4L2: 57,234,541–57,242,750, reverse strandCOXFA4L2STAC3: 57,243,458–57,251,187, reverse strandSTAC3: 57,249,609–57,296,484, reverse strandR3HDM2: 57,253,762–57,431,051, reverse strandINHBC: 57,434,700–57,452,067, forward strandINHBCINHBE: 57,452,323–57,459,280, forward strandINHBEGLI1: 57,459,783–57,472,268, forward strandGLI1ARHGAP9: 57,472,260–57,488,831, reverse strandARHGAP9MARS1: 57,475,445–57,517,702, forward strandMARS1DDIT3: 57,516,584–57,523,630, reverse strandDDIT3: 57,517,712–57,520,480, reverse strandMBD6: 57,520,710–57,530,614, forward strandDCTN2: 57,529,567–57,547,256, reverse strandKIF5A: 57,546,026–57,586,633, forward strandKIF5APIP4K2C: 57,591,161–57,603,418, forward strandPIP4K2CDTX3: 57,604,484–57,609,804, forward strandDTX3ARHGEF25: 57,610,111–57,617,245, forward strandARHGEF25: 57,615,280–57,626,125, forward strandB4GALNT1: 57,623,409–57,633,242, reverse strandOS9: 57,693,841–57,728,342, forward strandOS9AGAP2: 57,723,761–57,742,209, reverse strandAGAP2TSPAN31: 57,738,013–57,751,383, forward strandTSPAN31CDK4: 57,746,043–57,756,013, reverse strandCDK4Diagram of STAC3: 12 exons on the reverse strand of chromosome 12Exon 11: 1 known disease-causing siteExon 10: 2 known disease-causing sitesExon 9: 2 known disease-causing sitesExon 8: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 3: 4 known disease-causing sitesExon 12: 57,243,458–57,243,910, 453 basesExon 11: 57,244,088–57,244,225, 138 basesExon 10: 57,244,315–57,244,366, 52 basesExon 9: 57,244,537–57,244,622, 86 basesExon 8: 57,244,916–57,244,965, 50 basesExon 7: 57,245,145–57,245,211, 67 basesExon 6: 57,246,804–57,246,901, 98 basesExon 5: 57,248,126–57,248,198, 73 basesExon 4: 57,248,706–57,248,803, 98 basesExon 3: 57,249,041–57,249,308, 268 basesExon 2: 57,249,571–57,249,637, 67 basesExon 1: 57,250,993–57,251,187, 195 bases1211109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.6 kb of the gene's 7.7 kb; 1,095 of those bases code for the protein.

How a genome test reads STAC3

15

positions in STAC3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 7.7 kb of STAC3, introns included, not only the 1.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). STAC3 gene: SH3 and cysteine rich domain 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/stac3

Vancouver

Dante Labs. STAC3 gene: SH3 and cysteine rich domain 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/stac3

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