Trait

Sclerodactyly

Localized thickening and tightness of the skin of the fingers or toes.

Body system: Abnormality of the integument

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/sclerodactyly.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

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5 genes linked to Sclerodactyly

Changes in these genes cause rare conditions in which Sclerodactyly is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
LMNAlamin A/C	Always	In 1 condition
SMARCAD1SNF2 related chromatin remodeling ATPase with DExD box 1	Very often (80–99%)	In 1 condition
GJA1gap junction protein alpha 1	Often (30–79%)	In 1 condition
LBRlamin B receptor	Often (30–79%)	In 2 conditions
RSPO1R-spondin 1	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Thickened skin

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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