Trait
Scleroderma
A chronic autoimmune phenomenon characterized by fibrosis (or hardening) and vascular alterations of the skin.
Summary
- Also called
- Progressive systemic scleroderma, Pseudoscleroderma
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
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Get my Genome Test12 genes linked to Scleroderma
Changes in these genes cause rare conditions in which Scleroderma is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| LMNAlamin A/C | Very often (80–99%) | In 2 conditions |
| SLC29A3solute carrier family 29 member 3 | Very often (80–99%) | In 1 condition |
| CLCNKBchloride voltage-gated channel Kb | Rarely (1–4%) | In 1 condition |
| IGHG2immunoglobulin heavy constant gamma 2 (G2m marker) | Rarely (1–4%) | In 1 condition |
| IGKCimmunoglobulin kappa constant | Rarely (1–4%) | In 1 condition |
| LEMD3LEM domain containing 3 | Rarely (1–4%) | In 1 condition |
| SLC12A3solute carrier family 12 member 3 | Rarely (1–4%) | In 1 condition |
| LBRlamin B receptor | Not recorded | In 1 condition |
| PAHphenylalanine hydroxylase | Not recorded | In 1 condition |
| URODuroporphyrinogen decarboxylase | Not recorded | In 1 condition |
| UROSuroporphyrinogen III synthase | Not recorded | In 1 condition |
| WRNWRN RecQ like helicase | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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