Trait
Disproportionately short middle portion of limb
Clinical name: Mesomelia
Shortening of the middle parts of the limbs (forearm and lower leg) in relation to the upper and terminal segments.
Summary
- Also called
- Mesomelic limb shortening, Mesomelic shortening of limbs, Symmetric mesomelic limb shortness
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Disproportionately short middle portion of limb, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test27 genes linked to Disproportionately short middle portion of limb
Changes in these genes cause rare conditions in which Disproportionately short middle portion of limb is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACANaggrecan | Always | In 2 conditions |
| CREB3L1cAMP responsive element binding protein 3 like 1 | Always | In 1 condition |
| DVL3dishevelled segment polarity protein 3 | Always | In 1 condition |
| NXNnucleoredoxin | Always | In 2 conditions |
| PTBP1polypyrimidine tract binding protein 1 | Always | In 1 condition |
| ROR2ROR family WNT receptor 2 | Always | In 2 conditions |
| SIK3SIK family kinase 3 | Always | In 1 condition |
| PTH1Rparathyroid hormone 1 receptor | Very often (80–99%) | In 1 condition |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Very often (80–99%) | In 1 condition |
| SHOXSHOX homeobox | Very often (80–99%) | In 3 conditions |
| AFF3ALF transcription elongation factor 3 | Often (30–79%) | In 1 condition |
| DVL1dishevelled segment polarity protein 1 | Often (30–79%) | In 2 conditions |
| GPC6glypican 6 | Often (30–79%) | In 1 condition |
| LBRlamin B receptor | Often (30–79%) | In 1 condition |
| PRKG2protein kinase cGMP-dependent 2 | Often (30–79%) | In 1 condition |
| CTSKcathepsin K | Sometimes (5–29%) | In 1 condition |
| DHCR77-dehydrocholesterol reductase | Sometimes (5–29%) | In 1 condition |
| DONSONDNA replication fork stabilization factor DONSON | Sometimes (5–29%) | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Sometimes (5–29%) | In 1 condition |
| GLI3GLI family zinc finger 3 | Sometimes (5–29%) | In 1 condition |
| TONSLtonsoku like, DNA repair protein | Sometimes (5–29%) | In 2 conditions |
| IFT80intraflagellar transport 80 | Not recorded | In 1 condition |
| NEK1NIMA related kinase 1 | Not recorded | In 1 condition |
| TBX15T-box transcription factor 15 | Not recorded | In 1 condition |
| TRIP11thyroid hormone receptor interactor 11 | Not recorded | In 1 condition |
| WDR35WD repeat domain 35 | Not recorded | In 2 conditions |
| WNT5AWnt family member 5A | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks