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Gene

FXYD2

FXYD domain containing ion transport regulator 2

Summary

Cytogenetic location
11q23.3
Coordinates
Chromosome 11: 117,820,057–117,824,744 (GRCh38)
Exons
6 exons across 4.7 kb
Protein
66 amino acids
Also known as
MGC12372
Previous symbols
ATP1G1, HOMG2
MANE Select transcript
ENST00000292079.7NM_001680.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Familial Hypomagnesemia

    • Familial Primary Hypomagnesemia

      A group of inherited magnesium-wasting disorders caused by variants in genes such as CLDN16, CLDN19, TRPM6, CNNM2 and FXYD2; the CLDN16 and CLDN19 forms can progress to chronic kidney disease.

      • ClinGen rates the link moderate
      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Magnesium supplementation can control symptoms, and some forms need kidney function and eye monitoring.

How FXYD2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 11, with a bracket where FXYD2 sits. FXYD2 and 14 genes near it on chromosome 11, from 117,322,401 to 118,322,400.Chromosome 1111q23.3p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q25117.4 Mb117.6 Mb117.8 Mb118 Mb118.2 MbCEP164: 117,314,557–117,413,616, forward strandCEP164DSCAML1: 117,427,772–117,817,525, reverse strandDSCAML1FXYD2: 117,820,057–117,824,744, reverse strandFXYD2FXYD6-FXYD2: 117,820,163–117,876,667, reverse strandFXYD6-FXYD2FXYD6: 117,833,023–117,877,675, reverse strandFXYD6TMPRSS13: 117,900,641–117,929,459, reverse strandTMPRSS13IL10RA: 117,986,370–118,003,037, forward strandIL10RASMIM35: 118,003,634–118,088,299, reverse strandSMIM35TMPRSS4: 118,076,986–118,125,510, forward strandTMPRSS4SCN4B: 118,133,377–118,152,906, reverse strandSCN4BSCN2B: 118,162,806–118,176,653, reverse strandSCN2BJAML: 118,193,725–118,226,323, reverse strandJAMLMPZL3: 118,226,690–118,252,375, reverse strandMPZL3MPZL2: 118,253,416–118,264,536, reverse strandMPZL2CD3E: 118,304,701–118,316,175, forward strandCD3EDiagram of FXYD2: 6 exons on the reverse strand of chromosome 11Exon 6: 117,820,057–117,820,372, 316 basesExon 5: 117,820,666–117,820,696, 31 basesExon 4: 117,820,859–117,820,895, 37 basesExon 3: 117,822,406–117,822,480, 75 basesExon 2: 117,822,679–117,822,717, 39 basesExon 1: 117,824,654–117,824,744, 91 bases6543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.6 kb of the gene's 4.7 kb; 201 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FXYD2 gene: FXYD domain containing ion transport regulator 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/fxyd2

Vancouver

Dante Labs. FXYD2 gene: FXYD domain containing ion transport regulator 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/fxyd2

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