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Gene

ANXA11

annexin A11

Summary

Cytogenetic location
10q22.3
Coordinates
Chromosome 10: 80,150,889–80,205,537 (GRCh38)
Exons
16 exons across 54.6 kb
Protein
505 amino acids
Previous symbols
ANX11
MANE Select transcript
ENST00000422982.8NM_145868.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Amyotrophic Lateral Sclerosis (ALS)

    • Amyotrophic Lateral Sclerosis

      A neurodegenerative disorder of upper and lower motor neurons, occurring in sporadic and familial forms.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Tofersen (Qalsody, FDA 2023) for SOD1-ALS; ASO trials for C9orf72 and FUS; riluzole; edaravone; AMX0035 (sodium phenylbutyrate-taurursodiol); multidisciplinary ALS clinic care; respiratory support; genetic counseling for family members

How ANXA11 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where ANXA11 sits. ANXA11 and 11 genes near it on chromosome 10, from 79,678,213 to 80,678,212.Chromosome 1010q22.3p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.379.8 Mb80 Mb80.2 Mb80.4 Mb80.6 MbNUTM2B: 79,703,227–79,714,681, forward strandNUTM2BNUTM2E: 79,826,739–79,850,878, forward strandNUTM2ESFTPD: 79,936,423–79,983,996, reverse strandSFTPDTMEM254: 80,078,641–80,092,862, forward strandTMEM254PLAC9: 80,131,682–80,147,044, forward strandPLAC9ANXA11: 80,150,889–80,205,537, reverse strandANXA11MAT1A: 80,269,780–80,290,150, reverse strandMAT1ADYDC1: 80,336,105–80,356,760, reverse strandDYDC1DYDC2: 80,344,730–80,369,191, forward strandDYDC2PRXL2A: 80,406,443–80,437,115, forward strandPRXL2ATSPAN14: 80,453,875–80,533,178, forward strandTSPAN14SH2D4B: 80,537,902–80,646,560, forward strandSH2D4BDiagram of ANXA11: 16 exons on the reverse strand of chromosome 10Exon 4: 3 known disease-causing sitesExon 16: 80,150,889–80,155,912, 5,024 basesExon 15: 80,157,641–80,157,763, 123 basesExon 14: 80,157,967–80,158,025, 59 basesExon 13: 80,159,100–80,159,195, 96 basesExon 12: 80,161,935–80,162,028, 94 basesExon 11: 80,163,349–80,163,405, 57 basesExon 10: 80,163,534–80,163,613, 80 basesExon 9: 80,164,053–80,164,143, 91 basesExon 8: 80,166,084–80,166,197, 114 basesExon 7: 80,166,890–80,166,984, 95 basesExon 6: 80,167,226–80,167,313, 88 basesExon 5: 80,168,969–80,169,358, 390 basesExon 4: 80,170,800–80,170,915, 116 basesExon 3: 80,172,807–80,172,869, 63 basesExon 2: 80,176,107–80,176,155, 49 basesExon 1: 80,205,343–80,205,537, 195 bases16141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.7 kb of the gene's 54.6 kb; 1,518 of those bases code for the protein.

How a genome test reads ANXA11

4

positions in ANXA11 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 54.6 kb of ANXA11, introns included, not only the 6.7 kb of exons.

Genes linked to the same conditions

Traits linked to ANXA11

The Human Phenotype Ontology lists these as features of the rare conditions ANXA11 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ANXA11 gene: annexin A11. Retrieved 17 October 2026, from https://dantelabs.com/genes/anxa11

Vancouver

Dante Labs. ANXA11 gene: annexin A11 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/anxa11

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