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Gene

MYH2

myosin heavy chain 2

Summary

Cytogenetic location
17p13.1
Coordinates
Chromosome 17: 10,521,148–10,549,658 (GRCh38)
Exons
40 exons across 28.5 kb
Protein
1,941 amino acids
Also known as
MYH2A, MYHSA2, MyHC-IIa, MYHas8, MyHC-2A
Previous symbols
IBM3
MANE Select transcript
ENST00000245503.10NM_017534.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads MYH2 yet. The test sequences your whole genome, so your data includes it all the same.

How MYH2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where MYH2 sits. MYH2 and 11 genes near it on chromosome 17, from 10,035,403 to 11,035,402.Chromosome 1717p13.1p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.310.2 Mb10.4 Mb10.6 Mb10.8 Mb11 MbGAS7: 9,910,606–10,198,912, reverse strandGAS7MYH13: 10,300,865–10,373,130, reverse strandMYH13MYH8: 10,390,322–10,421,950, reverse strandMYH8MYH4: 10,443,290–10,469,559, reverse strandMYH4MYH1: 10,491,027–10,518,719, reverse strandMYH1MYH2: 10,521,148–10,549,658, reverse strandMYH2MYH3: 10,628,526–10,657,309, reverse strandMYH3SCO1: 10,672,474–10,698,375, reverse strandSCO1ADPRM: 10,697,247–10,713,286, forward strandADPRMTMEM220: 10,699,015–10,730,380, reverse strandTMEM220TMEM238L: 10,794,908–10,804,104, reverse strandTMEM238LPIRT: 10,822,470–10,838,106, reverse strandPIRTDiagram of MYH2: 40 exons on the reverse strand of chromosome 17Exon 39: 3 known disease-causing sitesExon 38: 2 known disease-causing sitesExon 37: 2 known disease-causing sitesExon 35: 2 known disease-causing sitesExon 34: 4 known disease-causing sitesExon 33: 1 known disease-causing siteExon 32: 8 known disease-causing sitesExon 31: 1 known disease-causing siteExon 30: 1 known disease-causing siteExon 29: 1 known disease-causing siteExon 28: 3 known disease-causing sitesExon 27: 3 known disease-causing sitesExon 26: 4 known disease-causing sitesExon 25: 3 known disease-causing sitesExon 24: 5 known disease-causing sitesExon 23: 1 known disease-causing siteExon 22: 8 known disease-causing sitesExon 21: 6 known disease-causing sitesExon 20: 1 known disease-causing siteExon 19: 3 known disease-causing sitesExon 18: 1 known disease-causing siteExon 17: 2 known disease-causing sitesExon 16: 4 known disease-causing sitesExon 15: 1 known disease-causing siteExon 14: 2 known disease-causing sitesExon 13: 1 known disease-causing siteExon 11: 3 known disease-causing sitesExon 8: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 3: 3 known disease-causing sitesExon 40: 10,521,148–10,521,432, 285 basesExon 39: 10,523,090–10,523,185, 96 basesExon 38: 10,523,308–10,523,412, 105 basesExon 37: 10,523,496–10,523,666, 171 basesExon 36: 10,523,759–10,523,884, 126 basesExon 35: 10,524,466–10,524,669, 204 basesExon 34: 10,524,757–10,525,065, 309 basesExon 33: 10,525,224–10,525,348, 125 basesExon 32: 10,525,451–10,525,616, 166 basesExon 31: 10,525,693–10,525,876, 184 basesExon 30: 10,526,599–10,526,795, 197 basesExon 29: 10,526,938–10,527,056, 119 basesExon 28: 10,527,748–10,527,874, 127 basesExon 27: 10,528,690–10,529,079, 390 basesExon 26: 10,529,162–10,529,252, 91 basesExon 25: 10,529,336–10,529,481, 146 basesExon 24: 10,529,564–10,529,740, 177 basesExon 23: 10,529,832–10,530,074, 243 basesExon 22: 10,531,633–10,531,888, 256 basesExon 21: 10,533,285–10,533,421, 137 basesExon 20: 10,533,509–10,533,632, 124 basesExon 19: 10,535,073–10,535,190, 118 basesExon 18: 10,535,278–10,535,365, 88 basesExon 17: 10,536,530–10,536,606, 77 basesExon 16: 10,537,233–10,537,542, 310 basesExon 15: 10,537,665–10,537,835, 171 basesExon 14: 10,539,205–10,539,354, 150 basesExon 13: 10,539,444–10,539,562, 119 basesExon 12: 10,539,928–10,540,066, 139 basesExon 11: 10,540,594–10,540,697, 104 basesExon 10: 10,542,875–10,542,973, 99 basesExon 9: 10,543,098–10,543,161, 64 basesExon 8: 10,543,711–10,543,803, 93 basesExon 7: 10,543,902–10,544,016, 115 basesExon 6: 10,544,100–10,544,127, 28 basesExon 5: 10,545,346–10,545,502, 157 basesExon 4: 10,547,475–10,547,618, 144 basesExon 3: 10,547,717–10,547,940, 224 basesExon 2: 10,549,375–10,549,417, 43 basesExon 1: 10,549,636–10,549,658, 23 bases40353025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6 kb of the gene's 28.5 kb; 5,826 of those bases code for the protein.

How a genome test reads MYH2

111

positions in MYH2 where ClinVar classes a change as pathogenic or likely pathogenic

19 of them (17%) fall in regions short reads find hard.

  • Low mappability (19 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.

A whole genome covers all 28.5 kb of MYH2, introns included, not only the 6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MYH2 gene: myosin heavy chain 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/myh2

Vancouver

Dante Labs. MYH2 gene: myosin heavy chain 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/myh2

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