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Gene

FGF23

fibroblast growth factor 23

Summary

Cytogenetic location
12p13.32
Coordinates
Chromosome 12: 4,368,227–4,379,712 (GRCh38)
Exons
3 exons across 11.5 kb
Protein
251 amino acids
MANE Select transcript
ENST00000237837.2NM_020638.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Rickets (Hypophosphatemic and Vitamin D-Dependent)

    • Hereditary hypophosphatemic rickets (including X-linked hypophosphatemia)

      Inherited disorders of phosphate handling, most often caused by PHEX variants (X-linked hypophosphatemia) and less often by FGF23, DMP1, ENPP1 or SLC34A3, that lead to low blood phosphate and rickets.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Treatment with oral phosphate and active vitamin D, or with the anti-FGF23 antibody burosumab, can improve bone health and growth.

How FGF23 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where FGF23 sits. FGF23 and 13 genes near it on chromosome 12, from 3,873,970 to 4,873,969.Chromosome 1212p13.32p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.334 Mb4.2 Mb4.4 Mb4.6 Mb4.8 MbCCND2: 4,269,755–4,306,933, forward strandCCND2: 4,273,762–4,405,490, forward strandTIGAR: 4,307,763–4,360,028, forward strandTIGARFGF23: 4,368,227–4,379,712, reverse strandFGF23FGF6: 4,428,155–4,445,816, reverse strandFGF6FERRY3: 4,487,735–4,538,519, reverse strandFERRY3RAD51AP1: 4,538,775–4,560,254, forward strandRAD51AP1DYRK4: 4,562,187–4,616,764, forward strandDYRK4: 4,604,944–4,662,643, forward strandAKAP3: 4,613,383–4,649,072, reverse strandAKAP3NDUFA9: 4,649,095–4,701,398, forward strandNDUFA9: 4,649,101–4,774,184, forward strandGALNT8: 4,719,870–4,851,927, forward strandGALNT8KCNA6: 4,809,334–4,813,318, forward strandKCNA6Diagram of FGF23: 3 exons on the reverse strand of chromosome 12Exon 3: 4 known disease-causing sitesExon 2: 1 known disease-causing siteExon 1: 2 known disease-causing sitesExon 3: 4,368,227–4,370,783, 2,557 basesExon 2: 4,372,594–4,372,697, 104 basesExon 1: 4,379,372–4,379,712, 341 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3 kb of the gene's 11.5 kb; 756 of those bases code for the protein.

How a genome test reads FGF23

8

positions in FGF23 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 11.5 kb of FGF23, introns included, not only the 3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FGF23 gene: fibroblast growth factor 23. Retrieved 17 October 2026, from https://dantelabs.com/genes/fgf23

Vancouver

Dante Labs. FGF23 gene: fibroblast growth factor 23 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/fgf23

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